Cesar Kenaan, Ph.D.

2012 University of Michigan, Ann Arbor, Ann Arbor, MI 
"Cesar Kenaan"
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Paul F. Hollenberg grad student 2012 University of Michigan
 (Investigating the effects and mechanisms of interaction between cytochrome P450 2B4, cytochrome P450 2E1 and cytochrome P450 reductase.)
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Lin HL, Zhang H, Kenaan C, et al. (2016) Mutation of F206 and V367 to Alanine in Human Cytochrome P450 2B6: Effects on the Selectivity of Androgen Hydroxylation, Mechanism-based Inactivation, and Reversible Inhibition. Drug Metabolism and Disposition: the Biological Fate of Chemicals
D'Agostino J, Zhang H, Kenaan C, et al. (2015) Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Chlorpyrifos. Chemical Research in Toxicology. 28: 1484-95
Lin HL, D'Agostino J, Kenaan C, et al. (2013) The effect of ritonavir on human CYP2B6 catalytic activity: heme modification contributes to the mechanism-based inactivation of CYP2B6 and CYP3A4 by ritonavir. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1813-24
Kenaan C, Zhang H, Hollenberg PF. (2013) High-throughput fluorescence assay for cytochrome P450 mechanism-based inactivators. Methods in Molecular Biology (Clifton, N.J.). 987: 61-9
Kenaan C, Shea EV, Lin HL, et al. (2013) Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 101-10
Lin HL, Kenaan C, Zhang H, et al. (2012) Reaction of human cytochrome P450 3A4 with peroxynitrite: nitrotyrosine formation on the proximal side impairs its interaction with NADPH-cytochrome P450 reductase. Chemical Research in Toxicology. 25: 2642-53
Sridar C, Kenaan C, Hollenberg PF. (2012) Inhibition of bupropion metabolism by selegiline: mechanism-based inactivation of human CYP2B6 and characterization of glutathione and peptide adducts. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 2256-66
Lin HL, Kenaan C, Hollenberg PF. (2012) Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 998-1006
Zhang H, Sridar C, Kenaan C, et al. (2011) Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: A charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome P450-reductase complex Journal of Pharmacology and Experimental Therapeutics. 338: 803-809
Kenaan C, Zhang H, Shea EV, et al. (2011) Uncovering the role of hydrophobic residues in cytochrome P450-cytochrome P450 reductase interactions. Biochemistry. 50: 3957-67
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