Amy E. Moritz, Ph.D.

Affiliations: 
2011 The University of North Dakota, Grand Forks, ND, United States 
Area:
Biochemistry
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Parents

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Roxanne A. Vaughan grad student 2011 University of North Dakota
 (Post-translational regulation of the dopamine transporter.)
David R. Sibley post-doc NIH (Neurotree)
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Publications

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Moritz AE, Bonifazi A, Guerrero AM, et al. (2020) Evidence for a stereoselective mechanism for bitopic activity by extended-length antagonists of the D3 dopamine receptor. Acs Chemical Neuroscience
Moritz AE, Free RB, Weiner WS, et al. (2020) Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. Journal of Medicinal Chemistry
Sanchez-Soto M, Verma RK, Willette BKA, et al. (2020) A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity. Science Signaling. 13
Bolland DE, Moritz AE, Stanislowski DJ, et al. (2019) Palmitoylation by multiple DHHC enzymes enhances dopamine transporter function and stability. Acs Chemical Neuroscience
Chun LS, Vekariya RH, Free RB, et al. (2018) Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the DDopamine Receptor. Frontiers in Synaptic Neuroscience. 10: 2
Moritz AE, Benjamin Free R, Sibley DR. (2017) Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds. Cellular Signalling
Kumar V, Moritz AE, Keck TM, et al. (2017) Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R). Journal of Medicinal Chemistry
Moritz AE, Rastedt DE, Stanislowski DJ, et al. (2015) Reciprocal Phosphorylation and Palmitoylation Control Dopamine Transporter Kinetics. The Journal of Biological Chemistry
Meade JA, Free RB, Miller NR, et al. (2015) (-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling. Psychopharmacology. 232: 917-30
Furman CA, Roof RA, Moritz AE, et al. (2014) Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
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