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Gaofei He, Ph.D.

Affiliations: 
2008 Carnegie Mellon University, Pittsburgh, PA 
Area:
Biochemistry
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"Gaofei He"
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Danith Ly grad student 2008 Carnegie Mellon
 (Development of conformationally-preorganized gamma-Peptide Nucleic Acid (gammaPNA) for recognition of double helical B-form DNA (B-DNA).)

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Publications

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He G, Tolic A, Bashkin JK, et al. (2015) Heterogeneous dynamics in DNA site discrimination by the structurally homologous DNA-binding domains of ETS-family transcription factors. Nucleic Acids Research. 43: 4322-31
Poon GM, Wang S, He G, et al. (2015) Unraveling the Structural, Dynamic, Thermodynamic, and Kinetic Heterogeneity in DNA Site Recognition by Structurally Homologous ETS Transcription Factors Biophysical Journal. 108: 75a-76a
Koeller KJ, Harris GD, Aston K, et al. (2014) DNA Binding Polyamides and the Importance of DNA Recognition in their use as Gene-Specific and Antiviral Agents. Medicinal Chemistry. 4: 338-344
He G, Vasilieva E, Harris GD, et al. (2014) Binding studies of a large antiviral polyamide to a natural HPV sequence. Biochimie. 102: 83-91
He G, Vasilieva E, Bashkin JK, et al. (2013) Mapping small DNA ligand hydroxyl radical footprinting and affinity cleavage products for capillary electrophoresis. Analytical Biochemistry. 439: 99-101
Bashkin JK, Aston K, Ramos JP, et al. (2013) Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine. Biochimie. 95: 271-9
Vasilieva E, He G, Koeller KJ, et al. (2013) 69 DNA-binding studies of large antiviral polyamides Journal of Biomolecular Structure and Dynamics. 31: 44-44
Dupureur CM, Bashkin JK, Aston K, et al. (2012) Fluorescence assay of polyamide-DNA interactions. Analytical Biochemistry. 423: 178-83
He G, Rapireddy S, Bahal R, et al. (2009) Strand invasion of extended, mixed-sequence B-DNA by gammaPNAs. Journal of the American Chemical Society. 131: 12088-90
Rapireddy S, He G, Roy S, et al. (2007) Strand invasion of mixed-sequence B-DNA by acridine-linked, gamma-peptide nucleic acid (gamma-PNA). Journal of the American Chemical Society. 129: 15596-600
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