Sujith V. Weerasinghe, Ph.D.

Affiliations: 
2009 Chemistry Wayne State University, Detroit, MI, United States 
Area:
Biochemistry
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"Sujith Weerasinghe"
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Parents

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Mary Kay H. Pflum grad student 2009 Wayne State
 (Characterization of histone deacetylase 1 using mutagenesis and small molecules.)
Mohammed Bishr Omary post-doc University of Michigan
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Publications

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Kwan R, Brady GF, Brzozowski M, et al. (2017) Hepatocyte-Specific Deletion of Mouse Lamin A/C Leads to Male-Selective Steatohepatitis. Cellular and Molecular Gastroenterology and Hepatology. 4: 365-383
Weerasinghe SV, Park MJ, Portney DA, et al. (2016) Mouse genetic background contributes to hepatocyte susceptibility to Fas-mediated apoptosis. Molecular Biology of the Cell
Bieliauskas AV, Weerasinghe SV, Negmeldin AT, et al. (2016) Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid. Archiv Der Pharmazie
Kwan R, Chen L, Looi K, et al. (2015) PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding. Hepatology (Baltimore, Md.)
Weerasinghe SV, Jang YJ, Fontana RJ, et al. (2014) Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 307: G355-64
Weerasinghe SV, Ku NO, Altshuler PJ, et al. (2014) Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity. Journal of Cell Science. 127: 1464-75
Snider NT, Griggs NW, Singla A, et al. (2013) CD73 (ecto-5'-nucleotidase) hepatocyte levels differ across mouse strains and contribute to mallory-denk body formation. Hepatology (Baltimore, Md.). 58: 1790-800
Snider NT, Weerasinghe SV, Singla A, et al. (2011) Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation. The Journal of Cell Biology. 195: 217-29
Choi SE, Weerasinghe SV, Pflum MK. (2011) The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity. Bioorganic & Medicinal Chemistry Letters. 21: 6139-42
Weerasinghe SV, Moons DS, Altshuler PJ, et al. (2011) Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: heparin prevents and treats liver damage. Hepatology (Baltimore, Md.). 53: 1323-32
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