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Justin M. Holub, Ph.D.

Affiliations: 
2009 Chemistry New York University, New York, NY, United States 
Area:
Biochemistry, Cell Biology
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Kent Kirshenbaum grad student 2009 NYU
 (Bioconjugation to functionalize peptidomimetics: Peptoid-based selective estrogen receptor modulators.)

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Publications

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Pokhrel R, Tang T, Holub JM. (2020) Monitoring ligand-mediated helix 12 transitions within the human estrogen receptor α using bipartite tetracysteine display. Organic & Biomolecular Chemistry
Arachchige D, Holub JM. (2018) Synthesis and Biological Activity of Scyllatoxin-Based BH3 Domain Mimetics Containing Two Disulfide Linkages. The Protein Journal
Arachchige D, Margaret Harris M, Coon Z, et al. (2017) Role of single disulfide linkages in the folding and activity of scyllatoxin-based BH3 domain mimetics. Journal of Peptide Science : An Official Publication of the European Peptide Society
Holub JM, Larochelle JR, Appelbaum JS, et al. (2013) Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics. Biochemistry. 52: 9036-46
Levine PM, Carberry TP, Holub JM, et al. (2013) Crafting precise multivalent architectures Medchemcomm. 4: 493-509
Appelbaum JS, LaRochelle JR, Smith BA, et al. (2012) Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm. Chemistry & Biology. 19: 819-30
Holub JM, Garabedian MJ, Kirshenbaum K. (2011) Modulation of human estrogen receptor α activity by multivalent estradiol-peptidomimetic conjugates. Molecular Biosystems. 7: 337-45
Holub JM, Kirshenbaum K. (2010) Tricks with clicks: modification of peptidomimetic oligomers via copper-catalyzed azide-alkyne [3 + 2] cycloaddition. Chemical Society Reviews. 39: 1325-37
Jagasia R, Holub JM, Bollinger M, et al. (2009) Peptide cyclization and cyclodimerization by Cu(I)-mediated azide-alkyne cycloaddition. The Journal of Organic Chemistry. 74: 2964-74
Holub JM, Jang H, Kirshenbaum K. (2007) Fit to be tied: conformation-directed macrocyclization of peptoid foldamers. Organic Letters. 9: 3275-8
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