David P. Lane
Affiliations: | Institute of Molecular and Cell Biology (A-STAR), Singapore, Singapore |
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"David Lane"Bio:
Institute of Molecular and Cell Biology (A-STAR), Proteos, 61 Biopolis Drive, Singapore 138673
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Cross-listing: Computational Biology Tree
Parents
Sign in to add mentor| Nicholas Avrion Mitchison | grad student | UCL (London) (Cell Biology Tree) |
Children
Sign in to add trainee| Ted Hupp | post-doc | (Neurotree) | |
| Jonathan Wilson Yewdell | post-doc | Imperial College (Cell Biology Tree) |
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Publications
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| Philippe GJ, Huang YH, Mittermeier A, et al. (2024) Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of Medicinal Chemistry |
| Ladds MJGW, van Leeuwen IMM, Drummond CJ, et al. (2023) Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage. Nature Communications. 14: 5019 |
| Lerma Clavero A, Boqvist PL, Ingelshed K, et al. (2023) MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia. Scientific Reports. 13: 4583 |
| Lane DP, Verma CS. (2023) Covalent Rescue of Mutant p53. Cancer Discovery. 13: 14-16 |
| Ingelshed K, Spiegelberg D, Kannan P, et al. (2022) The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth and Potentiates Radiotherapy. Cancer Research Communications. 2: 1075-1088 |
| Kaldmäe M, Vosselman T, Zhong X, et al. (2022) A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder. Structure (London, England : 1993) |
| Wang YH, Ho TLF, Hariharan A, et al. (2022) Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity. Proceedings of the National Academy of Sciences of the United States of America. 119: e2113233119 |
| Jiang L, Ingelshed K, Shen Y, et al. (2021) CRISPR/Cas9-induced DNA damage enriches for mutations in a p53-linked interactome: implications for CRISPR-based therapies. Cancer Research |
| Bhatta B, Luz I, Krueger C, et al. (2021) Cancer Cells Shuttle Extracellular Vesicles Containing Oncogenic Mutant p53 Proteins to the Tumor Microenvironment. Cancers. 13 |
| Ladds MJGW, Popova G, Pastor-Fernández A, et al. (2020) Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology. The Journal of Biological Chemistry. 295: 17935-17949 |