Michael J. Emanuele, Ph.D.
Affiliations: | 2007 | University of Virginia, Charlottesville, VA | |
| 2013- | Pharmacology | University of North Carolina, Chapel Hill, Chapel Hill, NC |
Area:
cell cycle, mitosis, protein stability, ubiquitin, cancer, genetics, cell biologyWebsite:
https://www.med.unc.edu/pharm/people/primaryfaculty/michael-j.-emanueleGoogle:
"Michael J. Emanuele"Bio:
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Parents
Sign in to add mentor| Peter Todd Stukenberg | grad student | 2007 | UVA | |
| (Biochemical and functional analysis of the vertebrate kinetochore.) | ||||
| Stephen J. Elledge | post-doc | 2013 | Harvard Medical School | |
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Publications
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| Nachum-Raines S, Gamliel N, Wasserman D, et al. (2025) Cdk1 and PP2A constitute a molecular switch controlling orderly degradation of atypical E2Fs. Biorxiv : the Preprint Server For Biology |
| Bolhuis DL, Fleifel D, Bonacci T, et al. (2024) USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination. Biorxiv : the Preprint Server For Biology |
| Mouery RD, Lukasik K, Hsu C, et al. (2024) Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton. Cell Reports. 43: 114510 |
| Mouery RD, Hsu C, Bonacci T, et al. (2023) Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control. Biorxiv : the Preprint Server For Biology |
| Enrico TP, Stallaert W, Wick ET, et al. (2021) Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2. Elife. 10 |
| Wasserman D, Nachum S, Noach-Hirsh M, et al. (2021) Elucidating Human Mitosis Using an Anaphase-Like Cell-Free System. Methods in Molecular Biology (Clifton, N.J.). 2329: 143-164 |
| Franks JL, Martinez-Chacin RC, Wang X, et al. (2020) In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators. Plos Biology. 18: e3000975 |
| Emanuele MJ, Enrico TP, Mouery RD, et al. (2020) Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin. Trends in Cell Biology |
| Martinez-Chacin RC, Bodrug T, Bolhuis DL, et al. (2020) Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming. Nature Structural & Molecular Biology |
| Bonacci T, Emanuele MJ. (2020) Dissenting degradation: Deubiquitinases in cell cycle and cancer. Seminars in Cancer Biology |