John G. Tooley, Ph.D.

Affiliations: 
2011 University of Virginia, Charlottesville, VA 
Area:
Cell Biology, Biochemistry
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Peter Todd Stukenberg grad student 2011 UVA
 (An analysis of spindle microtubule interactions mediated by the Ndc80 complex, Cep57R and Cep57.)
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Publications

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Nevitt C, Tooley JG, Schaner Tooley CE. (2018) N-terminal acetylation and methylation differentially affect the function of MYL9. The Biochemical Journal
Shields KM, Tooley JG, Petkowski JJ, et al. (2017) Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation. Protein Science : a Publication of the Protein Society
Janczyk PŁ, Skorupka KA, Tooley JG, et al. (2017) Mechanism of Ska Recruitment by Ndc80 Complexes to Kinetochores. Developmental Cell. 41: 438-449.e4
Tooley JG, Schaner Tooley CE. (2014) New roles for old modifications: emerging roles of N-terminal post-translational modifications in development and disease. Protein Science : a Publication of the Protein Society. 23: 1641-9
Petkowski JJ, Bonsignore LA, Tooley JG, et al. (2013) NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1. The Biochemical Journal. 456: 453-62
Tooley JG, Trent JO, Tooley CES. (2013) Abstract 5386: Investigating the role of N-terminal protein methylation in colon cancer progression. Cancer Research. 73: 5386-5386
Alushin GM, Musinipally V, Matson D, et al. (2012) Multimodal microtubule binding by the Ndc80 kinetochore complex. Nature Structural & Molecular Biology. 19: 1161-7
Tooley JG, Miller SA, Stukenberg PT. (2011) The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement. Molecular Biology of the Cell. 22: 1217-26
Tooley J, Stukenberg PT. (2011) The Ndc80 complex: integrating the kinetochore's many movements. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 19: 377-91
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