Edward A. Motea, Ph.D.
Affiliations: | 2012 | Chemistry | Case Western Reserve University, Cleveland Heights, OH, United States |
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Parents
Sign in to add mentorIrene Lee | grad student | 2012 | Case Western | |
(Probing the chemistry and enzymology of translesion DNA synthesis: Applications in developing a novel "theranostic" agent against leukemia.) |
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Publications
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Wettasinghe AP, Singh N, Starcher CL, et al. (2021) Detecting Attomolar DNA-Damaging Anticancer Drug Activity in Cell Lysates with Electrochemical DNA Devices. Acs Sensors |
Starcher CL, Pay SL, Singh N, et al. (2020) Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer. Frontiers in Oncology. 10: 1575 |
Patidar PL, Viera T, Morales JC, et al. (2020) XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. Scientific Reports. 10: 14253 |
Singh N, Pay SL, Bhandare SB, et al. (2020) Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy. Cancers. 12 |
Motea EA, Huang X, Singh N, et al. (2019) NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research |
Motea EA, Fattah FJ, Xiao L, et al. (2018) Kub5-Hera RPRD1B deficiency promotes "BRCAness" and vulnerability to PARP inhibition in BRCA-proficient Breast Cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research |
Choi JS, Kim S, Motea E, et al. (2017) Inhibiting translesion DNA synthesis as an approach to combat drug resistance to DNA damaging agents. Oncotarget |
Huang X, Motea EA, Moore ZR, et al. (2016) Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors. Cancer Cell. 30: 940-952 |
Morales JC, Richard P, Patidar PL, et al. (2016) XRN2 Links Transcription Termination to DNA Damage and Replication Stress. Plos Genetics. 12: e1006107 |
Patidar PL, Motea EA, Fattah FJ, et al. (2016) The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair. Nucleic Acids Research |