Nicholas Pagano, Ph.D.

Affiliations: 
2009 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Organic Chemistry, Biochemistry, Inorganic Chemistry
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"Nicholas Pagano"
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Parents

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Christian Hamann research assistant 2003-2004 Albright College
Eric Meggers grad student 2005-2009 Penn
 (Ruthenium half -sandwich complexes as protein kinase inhibitors.)
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Publications

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Martin EK, Pagano N, Sherlock ME, et al. (2014) Synthesis and anticancer activity of ruthenium half-sandwich complexes comprising combined metal centrochirality and planar chirality Inorganica Chimica Acta. 423: 530-539
John JK, Paraiso KH, Rebecca VW, et al. (2012) GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation. The Journal of Investigative Dermatology. 132: 2818-27
Rodrik-Outmezguine VS, Chandarlapaty S, Pagano NC, et al. (2011) mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling. Cancer Discovery. 1: 248-59
Pagano N, Wong EY, Breiding T, et al. (2009) From imide to lactam metallo-pyridocarbazoles: distinct scaffolds for the design of selective protein kinase inhibitors. The Journal of Organic Chemistry. 74: 8997-9009
Bullock AN, Russo S, Amos A, et al. (2009) Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. Plos One. 4: e7112
Xie P, Streu C, Qin J, et al. (2009) The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase. Biochemistry. 48: 5187-98
Anand R, Maksimoska J, Pagano N, et al. (2009) Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor. Journal of Medicinal Chemistry. 52: 1602-11
Schlegel MK, Zhang L, Pagano N, et al. (2009) Metal-mediated base pairing within the simplified nucleic acid GNA. Organic & Biomolecular Chemistry. 7: 476-82
Atilla-Gokcumen GE, Pagano N, Streu C, et al. (2008) Extremely tight binding of a ruthenium complex to glycogen synthase kinase 3. Chembiochem : a European Journal of Chemical Biology. 9: 2933-6
Atilla-Gokcumen GE, Pagano N, Streu C, et al. (2008) Cover Picture: Extremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3 (ChemBioChem 18/2008) Chembiochem. 9: 2897-2897
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