Mark Swingle, Ph.D.

Affiliations: 
2006 University of South Alabama, Mobile, AL, United States 
Area:
Biochemistry
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Richard Honkanen grad student 2006 University of South Alabama
 (Structure of protein phosphatase 5.)
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Publications

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Shuhaibar LC, Kaci N, Egbert JR, et al. (2021) Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth. Jci Insight. 6
Papke CM, Smolen KA, Swingle MR, et al. (2021) A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth. The Journal of Biological Chemistry. 100313
D'Arcy BM, Swingle MR, Schambeau L, et al. (2019) Development of a Synthetic 3-ketosteroid Δ-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. Scientific Reports. 9: 5969
D'Arcy BM, Swingle MR, Papke CM, et al. (2019) The Antitumor Drug LB-100 is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Catalytic Metals in the Active Site of PP5C. Molecular Cancer Therapeutics
Swingle MR, Honkanen RE. (2018) Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development. Current Medicinal Chemistry
Choy MS, Swingle M, D'Arcy B, et al. (2017) The PP1:tautomycetin complex reveals a path towards the development of PP1-specific inhibitors. Journal of the American Chemical Society
Swingle M, Volmar CH, Saldanha SA, et al. (2016) An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C). Journal of Biomolecular Screening
Chattopadhyay D, Swingle MR, Salter EA, et al. (2016) Crystal Structures and Mutagenesis of PPP-family ser/thr Protein Phosphatases Elucidate the Selectivity of Cantharidin and Novel Norcantharidin-based Inhibitors of PP5C. Biochemical Pharmacology
Swingle MR, Honkanen RE. (2014) Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C). Assay and Drug Development Technologies. 12: 481-96
Yang X, Liu Y, Yang XM, et al. (2011) Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity. Basic Research in Cardiology. 106: 421-30
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