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Kaiyan Lou, Ph.D.

Affiliations: 
2007 Department of Chemistry Kansas State University, Manhattan, KS, United States 
Area:
Organic Chemistry
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"Kaiyan Lou"
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Duy Hua grad student 2007 Kansas State University
 (Syntheses of novel antitumor 1,4-anthracenediones and functionized cyclododeciptycene based molecular gears.)

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Publications

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Lou K, Prior AM, Wiredu B, et al. (2010) Synthesis of cyclododeciptycene quinones. Journal of the American Chemical Society. 132: 17635-41
Hua DH, Zhao H, Battina SK, et al. (2008) Total syntheses of (+/-)-ovalicin, C4(S *)-isomer, and its C5-analogs and anti-trypanosomal activities. Bioorganic & Medicinal Chemistry. 16: 5232-46
Perchellet EM, Wang Y, Lou K, et al. (2007) Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition. Anticancer Research. 27: 3259-71
Perchellet EM, Wang Y, Lou K, et al. (2007) Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria. International Journal of Oncology. 31: 1231-41
Yamada T, Komoto J, Lou K, et al. (2007) Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents. Biochemical Pharmacology. 73: 981-9
Hua DH, Lou K, Battina SK, et al. (2006) Syntheses, molecular targets and antitumor activities of novel triptycene bisquinones and 1,4-anthracenedione analogs. Anti-Cancer Agents in Medicinal Chemistry. 6: 303-18
Wang Y, Perchellet EM, Ward MM, et al. (2006) Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria. International Journal of Oncology. 28: 161-72
Wang Y, Perchellet EM, Ward MM, et al. (2005) Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones. Anti-Cancer Drugs. 16: 953-67
Perchellet EM, Wang Y, Weber RL, et al. (2004) Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling. Anti-Cancer Drugs. 15: 929-46
Perchellet EM, Wang Y, Weber RL, et al. (2004) Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling. Biochemical Pharmacology. 67: 523-37
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