Angelo Aguilar, Ph.D.
Affiliations: | 2008 | Department of Chemistry | Kansas State University, Manhattan, KS, United States |
Area:
Organic ChemistryGoogle:
"Angelo Aguilar"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Duy Hua | grad student | 2008 | Kansas State University | |
| (Progress toward the total synthesis of (+)-myriceric acid A.) | ||||
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Publications
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| Xu S, Aguilar A, Huang L, et al. (2020) Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong Antitumor Activity. Journal of Medicinal Chemistry |
| Yang J, Li Y, Aguilar A, et al. (2019) Simple Structural Modifications Converting a Bona Fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. Journal of Medicinal Chemistry |
| Aguilar A, Zheng K, Xu T, et al. (2019) Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. Journal of Medicinal Chemistry |
| Li Y, Yang J, Aguilar A, et al. (2018) Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. Journal of Medicinal Chemistry |
| Zhao Y, Zhou B, Bai L, et al. (2018) Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. Journal of Medicinal Chemistry |
| Yang J, Li Y, Aguilar A, et al. (2018) Abstract 4870: Targeted MDM2 degradation as a novel and efficacious cancer therapy Cancer Research. 78: 4870-4870 |
| Wang S, Xu S, Aguilar A, et al. (2017) Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angewandte Chemie (International Ed. in English) |
| Aguilar A, Lu J, Liu L, et al. (2017) Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development. Journal of Medicinal Chemistry |
| Wang S, Zhao Y, Aguilar A, et al. (2017) Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges. Cold Spring Harbor Perspectives in Medicine |
| Lu J, Aguilar A, Zou B, et al. (2015) Chemical synthesis of tetracyclic terpenes and evaluation of antagonistic activity on endothelin-A receptors and voltage-gated calcium channels. Bioorganic & Medicinal Chemistry. 23: 5985-98 |