Shelli R. McAlpine

Affiliations: 
2000-2011 Chemistry (Joint Doctoral SDSU) University of California, San Diego and San Diego State University 
 2011- Chemistry University of New South Wales (Australia), Kensington, New South Wales, Australia 
Area:
Organic Chemistry, Chemical Biology, Chaperones, peptide chemistry
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"Shelli McAlpine"
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Parents

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Miguel A. Garcia-Garibay grad student 1993-1997 UCLA
Stuart L. Schreiber post-doc 1997-2000 Harvard

Children

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Kristina Cook research assistant 2003-2005 University of California, San Diego and San Diego State University
Michelle Cheung grad student 2015- University of New South Wales (Australia)
Vanessa Hunt grad student 2015- University of New South Wales (Australia)
Jennifer Robinson grad student 2002-2004 University of California, San Diego and San Diego State University
Lisa Liotta grad student 2002-2005 University of California, San Diego and San Diego State University
Katerina Otrubova grad student 2004-2007 University of California, San Diego and San Diego State University
Ahmet Kekec grad student 2005-2007 University of California, San Diego and San Diego State University
Po-Shen Pan grad student 2008 University of California, San Diego and San Diego State University
Stephanie Lapera grad student 2006-2008 University of California, San Diego and San Diego State University
Melinda Davis grad student 2007-2009 University of California, San Diego and San Diego State University
Suchitra Ravula grad student 2007-2010 University of California, San Diego and San Diego State University
Victoria Johnson grad student 2008-2011 University of California, San Diego and San Diego State University
Chung Mao Pan grad student 2007-2012 University of California, San Diego and San Diego State University
Erin Singh grad student 2007-2012 University of California, San Diego and San Diego State University
Leslie Alexander grad student 2008-2012 University of California, San Diego and San Diego State University
Marbie Guillergan grad student 2009-2012 University of California, San Diego and San Diego State University
Jeremiah savage grad student 2009-2012 University of California, San Diego and San Diego State University
Robert Sellers grad student 2009-2012 University of California, San Diego and San Diego State University
Chun Chieh Lin grad student 2009-2013 University of California, San Diego and San Diego State University
Worawan Tantisantisom grad student 2011-2013 University of New South Wales, Australia
Seong Jong Kim grad student 2011-2014 University of New South Wales (Australia)
Hendra Wahyudi grad student 2011-2014 University of New South Wales, Australia
Md. Amirul Islam grad student 2011-2015 University of New South Wales (Australia)
Jeannette McConnell grad student 2011-2015 University of New South Wales (Australia)
Yen Chin Koay grad student 2012-2016 University of New South Wales (Australia)
Yao Wang grad student 2012-2016 University of New South Wales (Australia)
Laura Buckton grad student 2014-2018 University of New South Wales (Australia)
Adrian Pietkiewicz grad student 2014-2018 University of New South Wales, Australia
Yuantao Huo grad student 2016-2018 University of New South Wales, Australia
Yuqi Zhang grad student 2014-2019 University of New South Wales, Australia
Veronica C. Ardi post-doc 2009-2010 University of California, San Diego and San Diego State University (Microtree)
Deborah E. Ramsey post-doc 2011-2014 University of New South Wales, Australia (SocTree)
Enrique Azevedo research scientist 2001-2003 University of California, San Diego and San Diego State University
Robert Vasko research scientist 2007-2010 University of California, San Diego and San Diego State University
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Publications

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Kataria N, Martinez CA, Kerr B, et al. (2019) C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1α through the Oxygen-Dependent Degradation Pathway. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 53: 480-495
Rahimi MN, Foster HG, Farazi SN, et al. (2019) Polymer mediated transport of the Hsp90 inhibitor LB76, a polar cyclic peptide, produces an Hsp90 cellular phenotype. Chemical Communications (Cambridge, England)
Huo Y, Buckton LK, Bennett JL, et al. (2019) Delivering bioactive cyclic peptides that target Hsp90 as prodrugs. Journal of Enzyme Inhibition and Medicinal Chemistry. 34: 728-739
Rahimi MN, McAlpine SR. (2018) Protein-protein inhibitor designed de novo to target the MEEVD region on the C-terminus of Hsp90 and block co-chaperone activity. Chemical Communications (Cambridge, England)
Rahimi MN, Buckton LK, Zaiter SS, et al. (2018) Synthesis and Structure-Activity Relationships of Inhibitors That Target the C-Terminal MEEVD on Heat Shock Protein 90. Acs Medicinal Chemistry Letters. 9: 73-77
Zaiter S, Huo Y, Tiew FY, et al. (2018) Designing de novo small molecules that control Heat shock protein 70 (Hsp70) and Heat shock organizing protein (HOP) within the chaperone protein-folding machinery. Journal of Medicinal Chemistry
Lauwers E, Wang YC, Gallardo R, et al. (2018) Hsp90 Mediates Membrane Deformation and Exosome Release. Molecular Cell. 71: 689-702.e9
Buckton LK, McAlpine SR. (2018) Improving the Cell Permeability of Polar Cyclic Peptides by Replacing Residues with Alkylated Amino Acids, Asparagines, and d-Amino Acids. Organic Letters
Pietkiewicz AL, Zhang Y, Rahimi MN, et al. (2017) RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles. Acs Medicinal Chemistry Letters. 8: 401-406
Wang Y, Koay YC, McAlpine SR. (2017) How selective are heat shock protein 90 (Hsp90) inhibitors for cancer cells over normal cells? Chemmedchem
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