Jignesh M. Doshi, Ph.D.
Affiliations: | 2008 | Medicinal Chemistry | University of Minnesota, Twin Cities, Minneapolis, MN |
Area:
Pharmaceutical Chemistry, Organic ChemistryGoogle:
"Jignesh Doshi"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Chengguo Xing | grad student | 2008 | UMN | |
| (Rational design, synthesis, and biological evaluation of antagonists against anti-apoptotic Bcl-2 proteins.) | ||||
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Publications
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| Das SG, Srinivasan B, Hermanson DL, et al. (2011) Structure-activity relationship and molecular mechanisms of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and its analogues. Journal of Medicinal Chemistry. 54: 5937-48 |
| Das SG, Doshi JM, Tian D, et al. (2009) Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues. Journal of Medicinal Chemistry. 52: 5937-49 |
| Tian D, Das SG, Doshi JM, et al. (2008) sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell. Cancer Letters. 259: 198-208 |
| Doshi JM, Xing C. (2008) Antagonists against anti-apoptotic Bcl-2 family proteins for cancer treatment Mini-Reviews in Organic Chemistry. 5: 171-178 |
| Doshi JM, Tian D, Xing C. (2007) Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis. Molecular Pharmaceutics. 4: 919-28 |
| Doshi JM, Tian D, Xing C. (2006) Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. Journal of Medicinal Chemistry. 49: 7731-9 |