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Shuxia Zhou, Ph.D.

Affiliations: 
2012 Pharmaceutical Chemistry University of Kansas, Lawrence, KS, United States 
Area:
Pharmacy, Biochemistry
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"Shuxia Zhou"
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Christian Schoneich grad student 2012 University of Kansas
 (Instability of Immunoglobulin G (IgG) Monoclonal Antibodies Induced by Redox-Active Metal Ions and Photo-Irradiation.)

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Mozziconacci O, Arora J, Toth Iv RT, et al. (2016) Site-specific hydrolysis reaction C-terminal of methionine in Met-His during metal-catalyzed oxidation of IgG-1. Molecular Pharmaceutics
Kumar S, Zhou S, Singh SK. (2014) Metal ion leachates and the physico-chemical stability of biotherapeutic drug products. Current Pharmaceutical Design. 20: 1173-81
Zhou S, Mozziconacci O, Kerwin BA, et al. (2013) Fluorogenic tagging methodology applied to characterize oxidized tyrosine and phenylalanine in an immunoglobulin monoclonal antibody. Pharmaceutical Research. 30: 1311-27
Zhou S, Mozziconacci O, Kerwin BA, et al. (2013) The photolysis of disulfide bonds in IgG1 and IgG2 leads to selective intramolecular hydrogen transfer reactions of cysteine Thiyl radicals, probed by covalent H/D exchange and RPLC-MS/MS analysis. Pharmaceutical Research. 30: 1291-9
Zhou S, Evans B, Schöneich C, et al. (2012) Biotherapeutic formulation factors affecting metal leachables from stainless steel studied by design of experiments. Aaps Pharmscitech. 13: 284-94
Zhou S, Schöneich C, Singh SK. (2011) Biologics formulation factors affecting metal leachables from stainless steel. Aaps Pharmscitech. 12: 411-21
Zhou S, Zhang B, Sturm E, et al. (2010) Comparative evaluation of disodium edetate and diethylenetriaminepentaacetic acid as iron chelators to prevent metal-catalyzed destabilization of a therapeutic monoclonal antibody. Journal of Pharmaceutical Sciences. 99: 4239-50
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