Hector Serrano, Ph.D.
Affiliations: | 2009 | Pharmacy | University of Texas at Austin, Austin, Texas, U.S.A. |
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Sign in to add mentorChristian P. Whitman | grad student | 2009 | UT Austin | |
(Characterization of the Activities of trans-3-Chloroacrylic Acid Dehalogenase and cis-3-Chloroacrylic Acid Dehalogenase and Malonate Semialdehyde Decarboxylase Homologues: Mechanism and Evolutionary Implications.) |
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Publications
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Poelarends GJ, Serrano H, Huddleston JP, et al. (2013) A mutational analysis of active site residues in trans-3-chloroacrylic acid dehalogenase. Febs Letters. 587: 2842-50 |
Guo Y, Serrano H, Poelarends GJ, et al. (2013) Kinetic, mutational, and structural analysis of malonate semialdehyde decarboxylase from Coryneform bacterium strain FG41: mechanistic implications for the decarboxylase and hydratase activities. Biochemistry. 52: 4830-41 |
Schroeder GK, Johnson WH, Huddleston JP, et al. (2012) Reaction of cis-3-chloroacrylic acid dehalogenase with an allene substrate, 2,3-butadienoate: hydration via an enamine. Journal of the American Chemical Society. 134: 293-304 |
Guo Y, Serrano H, Johnson WH, et al. (2011) Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase: Implications for the catalytic and inactivation mechanisms. Bioorganic Chemistry. 39: 1-9 |
Pegan SD, Serrano H, Whitman CP, et al. (2008) Structural and mechanistic analysis of trans-3-chloroacrylic acid dehalogenase activity. Acta Crystallographica. Section D, Biological Crystallography. 64: 1277-82 |
Poelarends GJ, Serrano H, Person MD, et al. (2008) Characterization of Cg10062 from Corynebacterium glutamicum: implications for the evolution of cis-3-chloroacrylic acid dehalogenase activity in the tautomerase superfamily. Biochemistry. 47: 8139-47 |
Poelarends GJ, Johnson WH, Serrano H, et al. (2007) Phenylpyruvate tautomerase activity of trans-3-chloroacrylic acid dehalogenase: evidence for an enol intermediate in the dehalogenase reaction? Biochemistry. 46: 9596-604 |
de Jong RM, Bazzacco P, Poelarends GJ, et al. (2007) Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase. Structural basis for substrate specificity and inactivation by (R)-oxirane-2-carboxylate. The Journal of Biological Chemistry. 282: 2440-9 |
Poelarends GJ, Almrud JJ, Serrano H, et al. (2006) Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural consequences of the L8R mutation in 4-oxalocrotonate tautomerase. Biochemistry. 45: 7700-8 |
Almrud JJ, Poelarends GJ, Johnson WH, et al. (2005) Crystal structures of the wild-type, P1A mutant, and inactivated malonate semialdehyde decarboxylase: a structural basis for the decarboxylase and hydratase activities. Biochemistry. 44: 14818-27 |