Matthew T. Labenski, Ph.D.

Affiliations: 
2008 Pharmacology & Toxicology University of Arizona, Tucson, AZ 
Area:
Toxicology
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Serrine S. Lau grad student 2008 University of Arizona
 (Identification and characterization of quinone-thioether protein adducts in vivo.)
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Publications

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Cohen JD, Labenski M, Mastrandrea NJ, et al. (2015) Transcriptional and post-translational modifications of B-Raf in quinol-thioether induced tuberous sclerosis renal cell carcinoma Molecular Carcinogenesis
Brown JM, Kuhlman C, Terneus MV, et al. (2014) S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry. Toxicology and Applied Pharmacology. 281: 174-84
Tjin Tham Sjin R, Lee K, Walter AO, et al. (2014) In vitro and in vivo characterization of irreversible mutant-selective EGFR inhibitors that are wild-type sparing. Molecular Cancer Therapeutics. 13: 1468-79
Arico-Muendel CC, Blanchette H, Benjamin DR, et al. (2013) Orally active fumagillin analogues: transformations of a reactive warhead in the gastric environment. Acs Medicinal Chemistry Letters. 4: 381-6
Walter AO, Sjin RT, Haringsma HJ, et al. (2013) Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discovery. 3: 1404-15
Evans EK, Tester R, Aslanian S, et al. (2013) Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans. The Journal of Pharmacology and Experimental Therapeutics. 346: 219-28
Nacht M, Qiao L, Sheets MP, et al. (2013) Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kα. Journal of Medicinal Chemistry. 56: 712-21
Arico-Muendel CC, Belanger B, Benjamin D, et al. (2013) Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 814-26
Fisher AA, Labenski MT, Malladi S, et al. (2011) The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation. Toxicological Sciences : An Official Journal of the Society of Toxicology. 122: 64-72
Hagel M, Niu D, St Martin T, et al. (2011) Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine. Nature Chemical Biology. 7: 22-4
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