Philip Ryan, Ph.D.

Affiliations: 
2008 Biochemistry and Molecular Genetics The George Washington University, Washington, DC, United States 
Area:
Molecular Biology, Cell Biology
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"Philip Ryan"
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Stan Lipkowitz grad student 2008 The George Washington University
 (Characterization of the ubiquitin ligase Cbl-c.)
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Publications

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Zhang H, Hao L, Yang J, et al. (2020) Comprehensive Electrical Control of Metamagnetic Transition of a Quasi-2D Antiferromagnet by In Situ Anisotropic Strain. Advanced Materials (Deerfield Beach, Fla.). e2002451
Daniels SR, Liyasova M, Kales SC, et al. (2019) Loss of function Cbl-c mutations in solid tumors. Plos One. 14: e0219143
Liyasova MS, Ma K, Voeller D, et al. (2019) Cbl interacts with multiple E2s in vitro and in cells. Plos One. 14: e0216967
Ryan PE, Kales SC, Yadavalli R, et al. (2012) Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5. Plos One. 7: e49428
Kales SC, Ryan PE, Lipkowitz S. (2012) Cbl exposes its RING finger. Nature Structural & Molecular Biology. 19: 131-3
Ryan PE, Sivadasan-Nair N, Nau MM, et al. (2010) The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme Journal of Biological Chemistry. 285: 23687-23698
Kales SC, Ryan PE, Nau MM, et al. (2010) Cbl and human myeloid neoplasms: the Cbl oncogene comes of age. Cancer Research. 70: 4789-94
Davies GC, Ryan PE, Rahman L, et al. (2006) EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins. Oncogene. 25: 6497-509
Ryan PE, Davies GC, Nau MM, et al. (2006) Regulating the regulator: negative regulation of Cbl ubiquitin ligases. Trends in Biochemical Sciences. 31: 79-88
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