Philip Ryan, Ph.D.
Affiliations: | 2008 | Biochemistry and Molecular Genetics | The George Washington University, Washington, DC, United States |
Area:
Molecular Biology, Cell BiologyGoogle:
"Philip Ryan"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Stan Lipkowitz | grad student | 2008 | The George Washington University | |
| (Characterization of the ubiquitin ligase Cbl-c.) | ||||
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Publications
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| Daniels SR, Liyasova M, Kales SC, et al. (2019) Loss of function Cbl-c mutations in solid tumors. Plos One. 14: e0219143 |
| Liyasova MS, Ma K, Voeller D, et al. (2019) Cbl interacts with multiple E2s in vitro and in cells. Plos One. 14: e0216967 |
| Ryan PE, Kales SC, Yadavalli R, et al. (2012) Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5. Plos One. 7: e49428 |
| Kales SC, Ryan PE, Lipkowitz S. (2012) Cbl exposes its RING finger. Nature Structural & Molecular Biology. 19: 131-3 |
| Ryan PE, Sivadasan-Nair N, Nau MM, et al. (2010) The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme Journal of Biological Chemistry. 285: 23687-23698 |
| Kales SC, Ryan PE, Nau MM, et al. (2010) Cbl and human myeloid neoplasms: the Cbl oncogene comes of age. Cancer Research. 70: 4789-94 |
| Davies GC, Ryan PE, Rahman L, et al. (2006) EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins. Oncogene. 25: 6497-509 |
| Ryan PE, Davies GC, Nau MM, et al. (2006) Regulating the regulator: negative regulation of Cbl ubiquitin ligases. Trends in Biochemical Sciences. 31: 79-88 |