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Christopher D. Lima

Affiliations: 
Weill Cornell Medical College, New York, NY, United States 
Area:
Biochemistry
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Parents

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Children

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Elena S. Mossessova grad student 2001 Weill Cornell Medical College
Meigang Gu grad student 2006 Weill Cornell Medical College
Jayakrishnan Nandakumar grad student 2007 Weill Cornell Medical College
Jaclyn C. Greimann grad student 2009 Weill Cornell Medical College
Firaz Mohideen grad student 2009 Weill Cornell Medical College
Ali A. Yunus grad student 2009 Weill Cornell Medical College
Jaclyn R. Gareau grad student 2012 Weill Cornell Medical College
Mi Seul Park post-doc 2020-

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Publications

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Lee HG, Lemmon AA, Lima CD. (2022) SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex. Proceedings of the National Academy of Sciences of the United States of America. 120: e2213703120
Puno MR, Lima CD. (2022) Methods to assess helicase and translocation activities of human nuclear RNA exosome and RNA adaptor complexes. Methods in Enzymology. 673: 453-473
Puno MR, Lima CD. (2022) Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex. Cell. 185: 2132-2147.e26
Das M, Zattas D, Zinder JC, et al. (2021) Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome. Proceedings of the National Academy of Sciences of the United States of America. 118
Weick EM, Lima CD. (2020) RNA helicases are hubs that orchestrate exosome-dependent 3'-5' decay. Current Opinion in Structural Biology. 67: 86-94
Januszyk K, Weick EM, Lima CD. (2020) Reconstitution of the Human Nuclear RNA Exosome. Methods in Molecular Biology (Clifton, N.J.). 2062: 467-489
Januszyk K, Lima CD. (2020) Reconstitution of the Schizosaccharomyces pombe RNA Exosome. Methods in Molecular Biology (Clifton, N.J.). 2062: 449-465
Zinder JC, Lima CD. (2020) Reconstitution of S. cerevisiae RNA Exosome Complexes Using Recombinantly Expressed Proteins. Methods in Molecular Biology (Clifton, N.J.). 2062: 427-448
Weick EM, Zinder JC, Lima CD. (2020) Strategies for Generating RNA Exosome Complexes from Recombinant Expression Hosts. Methods in Molecular Biology (Clifton, N.J.). 2062: 417-425
Puno MR, Lima CD. (2020) Cryo-EM Structure of Substrate-Engaged Nuclear Exosome Targeting (Next) Complex Biophysical Journal. 118: 489a
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