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Eddy Arnold

Chemistry and Chemical Biology Rutgers University, New Brunswick, New Brunswick, NJ, United States 
"Edward Van Dyke Arnold"

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Jon C. Clardy grad student 1982 Cornell
 (Structures and possible modes of action of two antitumor antibiotics: luzopeptin A and bryostatin l)
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Singh AK, De Wijngaert B, Bijnens M, et al. (2022) Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine. Proceedings of the National Academy of Sciences of the United States of America. 119: e2203660119
Harrison JJEK, Passos DO, Bruhn JF, et al. (2022) Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation. Science Advances. 8: eabn9874
Ruiz FX, Hoang A, Dilmore CR, et al. (2022) Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing. Drug Discovery Today
Losada N, Ruiz FX, Curreli F, et al. (2021) Correction to "HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites". Journal of Medicinal Chemistry
Losada N, Ruiz FX, Curreli F, et al. (2021) HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites. Journal of Medicinal Chemistry. 64: 16530-16540
Kang D, Ruiz FX, Sun Y, et al. (2021) 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies. Journal of Medicinal Chemistry
Himmel DM, Arnold E. (2020) Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV. Pharmaceuticals (Basel, Switzerland). 13
Nguyen PDM, Zheng J, Gremminger TJ, et al. (2020) Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase. Nucleic Acids Research
Xavier Ruiz F, Arnold E. (2020) Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance. Current Opinion in Structural Biology. 61: 113-123
Kang D, Ruiz FX, Feng D, et al. (2020) Discovery and Characterization of Fluorine-Substituted Diarylpyrimidines Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. Journal of Medicinal Chemistry
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