Jeffrey C. Culhane, Ph.D.

Affiliations: 
2008 Johns Hopkins University, Baltimore, MD 
Area:
Biochemistry, Organic Chemistry, Pharmaceutical Chemistry
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"Jeffrey Culhane"
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Philip A. Cole grad student 2008 Johns Hopkins
 (Suicide inactivation of the histone lysine demethylase LSD1 by peptide-based inactivators.)
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Publications

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Kong L, Kadam RU, Giang E, et al. (2015) Structure of hepatitis C virus envelope glycoprotein E1 antigenic site 314-324 in complex with antibody IGH526. Journal of Molecular Biology
Tarrant MK, Rho HS, Xie Z, et al. (2012) Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nature Chemical Biology. 8: 262-9
Culhane JC, Fokin VV. (2011) Synthesis and reactivity of sulfamoyl azides and 1-sulfamoyl-1,2,3-triazoles. Organic Letters. 13: 4578-80
Culhane JC, Wang D, Yen PM, et al. (2010) Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. Journal of the American Chemical Society. 132: 3164-76
Ebner DC, Culhane JC, Winkelman TN, et al. (2008) Synthesis of novel oxazolidinone antimicrobial agents. Bioorganic & Medicinal Chemistry. 16: 2651-6
Szewczuk LM, Saldanha SA, Ganguly S, et al. (2007) De novo discovery of serotonin N-acetyltransferase inhibitors. Journal of Medicinal Chemistry. 50: 5330-8
Culhane JC, Cole PA. (2007) LSD1 and the chemistry of histone demethylation. Current Opinion in Chemical Biology. 11: 561-8
Yang M, Culhane JC, Szewczuk LM, et al. (2007) Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry. 46: 8058-65
Yang M, Culhane JC, Szewczuk LM, et al. (2007) Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nature Structural & Molecular Biology. 14: 535-9
Szewczuk LM, Culhane JC, Yang M, et al. (2007) Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry. 46: 6892-902
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