Darren E. Casteel, Ph.D.

2003 University of California, San Diego, La Jolla, CA 
Molecular Biology, Cell Biology
"Darren Casteel"
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Renate B. Pilz grad student 2003 UCSD
 (Identification and characterization of G -kinase Ibeta interacting proteins.)
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Wahwah N, Dhar D, Chen H, et al. (2020) Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity. Scientific Reports. 10: 19907
Chan MH, Aminzai S, Hu T, et al. (2020) A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. The Journal of Biological Chemistry
Schwaerzer GK, Kalyanaraman H, Casteel DE, et al. (2019) Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B analog. Nature Communications. 10: 3533
Ramdani G, Schall N, Kalyanaraman H, et al. (2018) cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss. The Journal of Endocrinology
Kalyanaraman H, Schwaerzer G, Ramdani G, et al. (2018) Potein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes. Diabetes
Kalyanaraman H, Zhuang S, Pilz RB, et al. (2017) The Activity of cGMP-dependent Protein Kinase Iα is not Directly Regulated by Oxidation-induced Disulfide Formation at Cysteine 43. The Journal of Biological Chemistry
Sahu D, Gupta S, Hau AM, et al. (2016) Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase. The American Journal of Pathology
Kalyanaraman H, Ramdani G, Joshua J, et al. (2016) A Novel, Direct No Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research
Kim JJ, Lorenz R, Arold ST, et al. (2016) Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure (London, England : 1993)
Campbell JC, Kim JJ, Li KY, et al. (2016) Structural Basis of Cyclic Nucleotide Selectivity in cGMP-Dependent Protein Kinase II. The Journal of Biological Chemistry
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