Paul J. Sapienza, Ph.D.
Affiliations: | 2005 | University of Pittsburgh, Pittsburgh, PA, United States |
Area:
General Biophysics, Molecular BiologyGoogle:
"Paul Sapienza"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Linda J. Jacobson | grad student | 2005 | University of Pittsburgh | |
| (Themodynamic, kinetic, and structural basis for the relaxed DNA sequence specificity of "promiscuous" mutant EcoRI endonucleases.) | ||||
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Publications
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| Bonin JP, Sapienza PJ, Lee AL. (2022) Dynamic allostery in substrate binding by human thymidylate synthase. Elife. 11 |
| Bonin JP, Sapienza PJ, Wilkerson E, et al. (2019) Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase. Biophysical Journal |
| Sapienza PJ, Popov K, Mowrey DD, et al. (2019) Inter-Active Site Communication Mediated by the Dimer Interface Beta-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase. Biochemistry |
| Lee AL, Sapienza PJ. (2018) Thermodynamic and NMR Assessment of Ligand Cooperativity and Intersubunit Communication in Symmetric Dimers: Application to Thymidylate Synthase. Frontiers in Molecular Biosciences. 5: 47 |
| Sapienza PJ, Falk BT, Lee AL. (2015) Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity. Journal of the American Chemical Society |
| Sapienza PJ, Niu T, Kurpiewski MR, et al. (2014) Thermodynamic and structural basis for relaxation of specificity in protein-DNA recognition. Journal of Molecular Biology. 426: 84-104 |
| Sapienza PJ, Lee AL. (2014) Backbone and ILV methyl resonance assignments of E. coli thymidylate synthase bound to cofactor and a nucleotide analogue. Biomolecular Nmr Assignments. 8: 195-9 |
| Mauldin RV, Sapienza PJ, Petit CM, et al. (2012) Structure and dynamics of the G121V dihydrofolate reductase mutant: lessons from a transition-state inhibitor complex. Plos One. 7: e33252 |
| Sapienza PJ, Mauldin RV, Lee AL. (2011) Multi-timescale dynamics study of FKBP12 along the rapamycin-mTOR binding coordinate. Journal of Molecular Biology. 405: 378-94 |
| Sarver J, Stone K, Townsend J, et al. (2011) In the Arms of EcoRI - probing the Binding Specificity of the Restriction Endonuclease Using Electron Spin Resonance Biophysical Journal. 100 |