J. S. Imam, Ph.D.

Affiliations: 
2007 The University of Texas Graduate School of Biomedical Sciences at Houston 
Area:
Molecular Biology, Cell Biology, Immunology
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"J. Imam"
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Miles F. Wilkinson grad student 2007 The University of Texas Graduate School of Biomedical Sciences at Houston
 (Regulation of RNA splicing by nonsense mutations.)
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Publications

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Imam JS, Plyler JR, Bansal H, et al. (2012) Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization. Plos One. 7: e52397
Chang YF, Lee-Chang JS, Imam JS, et al. (2012) Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 109: 5750-5
Imam JS, Buddavarapu K, Lee-Chang JS, et al. (2010) MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers. Oncogene. 29: 4971-9
Imam JS, Gudikote JP, Chan WK, et al. (2010) Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruption. Nucleic Acids Research. 38: 1559-74
Chang YF, Chan WK, Imam JS, et al. (2007) Alternatively spliced T-cell receptor transcripts are up-regulated in response to disruption of either splicing elements or reading frame. The Journal of Biological Chemistry. 282: 29738-47
Chan WK, Huang L, Gudikote JP, et al. (2007) An alternative branch of the nonsense-mediated decay pathway. The Embo Journal. 26: 1820-30
Chang YF, Imam JS, Wilkinson MF. (2007) The nonsense-mediated decay RNA surveillance pathway. Annual Review of Biochemistry. 76: 51-74
Rao MK, Pham J, Imam JS, et al. (2006) Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes & Development. 20: 147-52
Gudikote JP, Imam JS, Garcia RF, et al. (2005) RNA splicing promotes translation and RNA surveillance. Nature Structural & Molecular Biology. 12: 801-9
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