Lawrence M. Szewczuk, Ph.D.
Affiliations: | 2004 | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Biochemistry, Medical BiophysicsGoogle:
"Lawrence Szewczuk"Mean distance: (not calculated yet)
Parents
Sign in to add mentorTrevor M. Penning | grad student | 2004 | Penn | |
(Selective mechanism -based inactivation of COX-1 by M-hydroquinones.) |
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Machutta CA, Kollmann CS, Lind KE, et al. (2017) Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening. Nature Communications. 8: 16081 |
Szewczuk LM, Penning TM. (2009) Co-oxidation by cyclooxygenases. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit4.30 |
Park JH, Gopishetty S, Szewczuk LM, et al. (2005) Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling. Chemical Research in Toxicology. 18: 1026-37 |
Szewczuk LM, Lee SH, Blair IA, et al. (2005) Viniferin formation by COX-1: evidence for radical intermediates during co-oxidation of resveratrol. Journal of Natural Products. 68: 36-42 |
Bauman DR, Rudnick SI, Szewczuk LM, et al. (2005) Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes. Molecular Pharmacology. 67: 60-8 |
Szewczuk LM, Penning TM. (2004) Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study. Journal of Natural Products. 67: 1777-82 |
Szewczuk LM, Forti L, Stivala LA, et al. (2004) Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. The Journal of Biological Chemistry. 279: 22727-37 |