Amy M. Quinn, Ph.D.

Affiliations: 
2008 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Pharmacology, Toxicology
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Trevor M. Penning grad student 2008 Penn
 (Role of aldo -keto reductase enzymes in polycyclic aromatic hydrocarbon trans-dihydrodiol activation in human lung cells.)
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Publications

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Kallander LS, Washburn D, Hilfiker MA, et al. (2018) Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1. Acs Medicinal Chemistry Letters. 9: 736-740
Wang L, Chang J, Varghese D, et al. (2013) A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nature Communications. 4: 2035
Wang L, Chang J, Varghese D, et al. (2013) Erratum: A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth Nature Communications. 4
Lu Q, Quinn AM, Patel MP, et al. (2012) Perspectives on the discovery of small-molecule modulators for epigenetic processes. Journal of Biomolecular Screening. 17: 555-71
Quinn AM, Simeonov A. (2011) Methods for Activity Analysis of the Proteins that Regulate Histone Methylation. Current Chemical Genomics. 5: 95-105
Shultz CA, Quinn AM, Park JH, et al. (2011) Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone. Chemical Research in Toxicology. 24: 2153-66
King ON, Li XS, Sakurai M, et al. (2010) Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. Plos One. 5: e15535
Liu F, Chen X, Allali-Hassani A, et al. (2010) Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. Journal of Medicinal Chemistry. 53: 5844-57
Quinn AM, Allali-Hassani A, Vedadi M, et al. (2010) A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors. Molecular Biosystems. 6: 782-8
Boxer MB, Quinn AM, Shen M, et al. (2010) A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety. Chemmedchem. 5: 730-8
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