James I. Fells, Ph.D.

Affiliations: 
2009 The University of Memphis, Memphis, TN, United States 
Area:
Pharmaceutical Chemistry
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Abby L. Parrill grad student 2009 The University of Memphis
 (Virtual screening of LPA receptor targets: An in silico approach to identify subtype selective antagonists.)
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Publications

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Yu W, Liu J, Clausen D, et al. (2021) Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity. Journal of Medicinal Chemistry
Clausen DJ, Liu J, Yu W, et al. (2020) Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir. Bioorganic & Medicinal Chemistry Letters. 30: 127367
Liu J, Kelly J, Yu W, et al. (2020) Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance. Acs Medicinal Chemistry Letters. 11: 1476-1483
Yu W, Liu J, Yu Y, et al. (2020) Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation. Bioorganic & Medicinal Chemistry Letters. 127197
Patil R, Szabó E, Fells JI, et al. (2015) Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist. Chemistry & Biology. 22: 206-16
Patil R, Fells JI, Szabó E, et al. (2014) Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor. Journal of Medicinal Chemistry. 57: 7136-40
Morales-Lázaro SL, Serrano-Flores B, Llorente I, et al. (2014) Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs. The Journal of Biological Chemistry. 289: 24079-90
Fells JI, Lee SC, Norman DD, et al. (2014) Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif. The Febs Journal. 281: 1017-28
Fells JI, Lee SC, Fujiwara Y, et al. (2013) Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface. Molecular Pharmacology. 84: 415-24
Kiss GN, Lee SC, Fells JI, et al. (2013) Mitigation of radiation injury by selective stimulation of the LPA(2) receptor. Biochimica Et Biophysica Acta. 1831: 117-25
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