Michael Smith, Ph.D.
Affiliations: | University of British Columbia | University of British Columbia, Vancouver, Vancouver, BC, Canada |
Area:
Nucleic acid chemistryWebsite:
http://www.nobelprize.org/nobel_prizes/chemistry/laureates/1993/smith-bio.htmlGoogle:
"chemistry nucleic acid site directed mutagenesis"Bio:
(1932 - 2000)
http://www.nasonline.org/member-directory/deceased-members/3001741.html
http://www.science.ca/scientists/scientistprofile.php?pID=18
The Nobel Prize in Chemistry 1993 was awarded "for contributions to the developments of methods within DNA-based chemistry" jointly with one half to Kary B. Mullis "for his invention of the polymerase chain reaction (PCR) method" and with one half to Michael Smith "for his fundamental contributions to the establishment of oligonucleotide-based, site-directed mutagenesis and its development for protein studies".
Mean distance: 7.85 | S | N | B | C | P |
Parents
Sign in to add mentor| Ewart Ray Herbert Jones | research assistant | University of Manchester | |
| H. Bernard Henbest | grad student | 1953-1956 | The University of Manchester |
| H. Gobind Khorana | post-doc | 1956-1961 | UBC |
Children
Sign in to add trainee| Louis Lefebvre | grad student | UBC (Neurotree) | |
| David A. Agard | post-doc | UBC | |
| John Richard Trevithick | post-doc | 1967 | UBC (Physiology Academic Tree) |
| David W. Russell | post-doc | 1980-1982 | UBC |
| Gary J. Pielak | post-doc | 1983-1986 | UBC |
| Christopher M. Overall | post-doc | 1989-1992 | UBC (Cell Biology Tree) |
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Publications
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| Ong E, Pollock WB, Smith M. (1997) Cloning and sequence analysis of two laccase complementary DNAs from the ligninolytic basidiomycete Trametes versicolor. Gene. 196: 113-9 |
| Maurus R, Overall CM, Bogumil R, et al. (1997) A myoglobin variant with a polar substitution in a conserved hydrophobic cluster in the heme binding pocket. Biochimica Et Biophysica Acta. 1341: 1-13 |
| Woods AC, Guy Guillemette J, Parrish JC, et al. (1996) Synergy in protein engineering: Mutagenic manipulation of protein structure to simplify semisynthesis Journal of Biological Chemistry. 271: 32008-32015 |
| Lo TP, Murphy ME, Guillemette JG, et al. (1995) Replacements in a conserved leucine cluster in the hydrophobic heme pocket of cytochrome c. Protein Science : a Publication of the Protein Society. 4: 198-208 |
| Berghuis AM, Guillemette JG, Smith M, et al. (1994) Mutation of tyrosine-67 to phenylalanine in cytochrome c significantly alters the local heme environment. Journal of Molecular Biology. 235: 1326-41 |
| Guillemette JG, Barker PD, Eltis LD, et al. (1994) Analysis of the bimolecular reduction of ferricytochrome c by ferrocytochrome b5 through mutagenesis and molecular modelling. Biochimie. 76: 592-604 |
| Lefebvre L, Smith M. (1993) Mutational and functional analysis of dominant SPT2 (SIN1) suppressor alleles in Saccharomyces cerevisiae. Molecular and Cellular Biology. 13: 5393-407 |
| Wallace CJA, Guillemette JG, Smith M, et al. (1992) Synergy of Semisynthesis and Site-Directed Mutagenesis: Manipulating Genes to Create Sites for Autocatalytic Protein Fragment Religation Techniques in Protein Chemistry. 209-217 |
| McIntosh EM, Atkinson T, Storms RK, et al. (1991) Characterization of a Short, cis-Acting DNA Sequence Which Conveys Cell Cycle Stage-Dependent Transcription in Saccharomyces cerevisiae Molecular and Cellular Biology. 11: 329-337 |
| Thurgood AG, Davies AM, Greenwood C, et al. (1991) NMR study of the structural characteristics of variants of yeast iso-1-cytochrome c in which unvaried aromatic residues have been substituted. European Journal of Biochemistry / Febs. 202: 339-47 |