Jeremy A. Goettel, Ph.D.

Affiliations: 
2010 Vanderbilt University, Nashville, TN 
Area:
Cell Biology, Biochemistry
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Steven K. Hanks grad student 2010 Vanderbilt
 (Kinase suppressor of Ras 1 is a functional protein kinase and protects from experimental colitis in mice by regulating T lymphocyte IFN-gamma production.)
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Publications

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Tyagi RK, Jacobse J, Li J, et al. (2021) HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice. Frontiers in Immunology. 12: 630204
Jacobse J, Li J, Tyagi RK, et al. (2020) 933 Interleukin-23 Receptor Signaling Modulates The Stability And Function Of Forkhead Box P3 Positive Regulatory T Cells Gastroenterology. 158
Tyagi RK, Li J, Jacobse J, et al. (2019) Humanized Mouse Models of Genetic Immune Disorders and Hematological Malignancies. Biochemical Pharmacology. 113671
Tsou A, Goettel J, Biswas A, et al. (2019) P155 Elucidating Interactions Between The Immune System And The Gut Microbiota In A Reductionist Murine Model Of Inflammatory Bowel Disease Gastroenterology. 156
Ryzhakov G, West NR, Franchini F, et al. (2018) Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis. Nature Communications. 9: 3797
Biswas A, Shouval DS, Griffith A, et al. (2018) WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nature Communications. 9: 1779
Shouval DS, Konnikova L, Griffith AE, et al. (2017) Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD. Inflammatory Bowel Diseases
Redhu NS, Bakthavatchalu V, Conaway EA, et al. (2017) Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 6
Goettel J, Kotlarz D, Illig D, et al. (2017) O-011 Low-dose IL-2 Administration Expands Human Regulatory T Cells in Patients with UC and Humanized Mice and Protects Against Experimental Colitis. Inflammatory Bowel Diseases. 23: S4
Thiagarajah JR, Chang J, Goettel JA, et al. (2017) Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proceedings of the National Academy of Sciences of the United States of America
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