Courtney G. Havens, Ph.D.
Affiliations: | 2006 | University of California, San Diego, La Jolla, CA |
Area:
Cell Biology, Molecular BiologyGoogle:
"Courtney Havens"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Steven Dowdy | grad student | 2006 | UCSD | |
| (Regulation of late G1/S phase transition and the anaphase promoting complex-Cdh1 by reactive oxygen species.) | ||||
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Publications
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| Wong L, Narla RK, Leisten J, et al. (2019) CC-92480, a Novel Cereblon E3 Ligase Modulator, Is Synergistic with Dexamethasone, Bortezomib, and Daratumumab in Multiple Myeloma Blood. 134: 1815-1815 |
| Lopez-Girona A, Havens CG, Lu G, et al. (2019) CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells Blood. 134: 1812-1812 |
| Bjorklund CC, Lu L, Kang J, et al. (2015) Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4. Blood Cancer Journal. 5: e354 |
| Hagner PR, Man HW, Fontanillo C, et al. (2015) CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL. Blood |
| Gandhi AK, Kang J, Havens CG, et al. (2014) Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). British Journal of Haematology. 164: 811-21 |
| Bjorklund CC, Havens CG, Hagner PR, et al. (2014) Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs® Immunomodulatory Compounds Blood. 124: 4700-4700 |
| Havens CG, Bjorklund C, Kang J, et al. (2014) IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance Blood. 124: 3432-3432 |
| Hagner P, Wang M, Couto S, et al. (2014) CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways Blood. 124: 3035-3035 |
| Salguero I, Guarino E, Shepherd ME, et al. (2012) Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen. Current Biology : Cb. 22: 720-6 |
| Havens CG, Shobnam N, Guarino E, et al. (2012) Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2. The Journal of Biological Chemistry. 287: 11410-21 |