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Bryan R. Meade, Ph.D.

Affiliations: 
2010 Biomedical Sciences University of California, San Diego, La Jolla, CA 
Area:
Biochemistry
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Steven Dowdy grad student 2010 UCSD
 (Synthesis of bioreversible, phosphotriester-modified siRNA oligonucleotides.)

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Publications

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Hagopian JC, Hamil AS, van den Berg A, et al. (2017) Induction of RNAi Responses by Short Left-Handed Hairpin RNAi Triggers. Nucleic Acid Therapeutics
Kaulich M, Lee YJ, Lönn P, et al. (2015) Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi. Nucleic Acids Research. 43: e45
Meade BR, Gogoi K, Hamil AS, et al. (2014) Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications. Nature Biotechnology. 32: 1256-61
Meade BR, Dowdy SF. (2009) The road to therapeutic RNA interference (RNAi): Tackling the 800 pound siRNA delivery gorilla. Discovery Medicine. 8: 253-6
Eguchi A, Meade BR, Chang YC, et al. (2009) Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein. Nature Biotechnology. 27: 567-71
Hagopian JC, Ma CT, Meade BR, et al. (2008) Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. Journal of Molecular Biology. 382: 894-909
Meade BR, Dowdy SF. (2008) Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides. Advanced Drug Delivery Reviews. 60: 530-6
Meade BR, Dowdy SF. (2007) Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides. Advanced Drug Delivery Reviews. 59: 134-40
Snyder EL, Saenz CC, Denicourt C, et al. (2005) Enhanced targeting and killing of tumor cells expressing the CXC chemokine receptor 4 by transducible anticancer peptides. Cancer Research. 65: 10646-50
Snyder EL, Meade BR, Saenz CC, et al. (2004) Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide. Plos Biology. 2: E36
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