Stewart Shuman

Affiliations: 
Weill Cornell Medical College, New York, NY, United States 
Area:
Molecular Biology, Biochemistry
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"Stewart Shuman"
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Publications

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Ghosh S, Wimberly-Gard G, Jacewicz A, et al. (2024) Identification, characterization, and structure of a tRNA splicing enzyme RNA 5'-OH kinase from the pathogenic fungi Mucorales. Rna (New York, N.Y.)
Arnold J, Ghosh S, Kasprzyk R, et al. (2024) Chemical synthesis of 2″OMeNAD+ and its deployment as an RNA 2'-phosphotransferase (Tpt1) 'poison' that traps the enzyme on its abortive RNA-2'-PO4-(ADP-2″OMe-ribose) reaction intermediate. Nucleic Acids Research
Ghosh S, Shuman S. (2024) Kinetic and structural insights into the requirement of fungal tRNA ligase for a 2'-phosphate end. Rna (New York, N.Y.)
Warren GM, Shuman S. (2024) Structure and psoralen DNA crosslink repair activity of mycobacterial Nei2. Mbio. e0124824
Schwer B, Innokentev A, Sanchez AM, et al. (2024) Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1. Mbio. e0125224
Ghosh S, Dantuluri S, Jacewicz A, et al. (2024) Characterization of tRNA splicing enzymes RNA ligase and tRNA 2'-phosphotransferase from the pathogenic fungi . Rna (New York, N.Y.)
Jacewicz A, Dantuluri S, Shuman S. (2023) Structural basis for Tpt1-catalyzed 2'-PO transfer from RNA and NADP(H) to NAD. Proceedings of the National Academy of Sciences of the United States of America. 120: e2312999120
Sanchez AM, Schwer B, Jork N, et al. (2023) Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase. Mbio. e0205623
Shuman S. (2023) RNA Repair: Hiding in Plain Sight. Annual Review of Genetics
Garg A, Schwer B, Shuman S. (2023) Fission yeast poly(A) polymerase active site mutation Y86D alleviates the synthetic growth defect and upregulates mRNAs targeted by MTREC and Mmi1. Rna (New York, N.Y.)
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