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Ligeng Tian, Ph.D.

Affiliations: 
2005 Weill Cornell Medical College, New York, NY, United States 
Area:
Molecular Biology
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"Ligeng Tian"
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Stewart Shuman grad student 2005 Weill Cornell Medical College
 (Delineating the functional interface between vaccinia topoisomerase and the substrate DNA.)

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Publications

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Tian L, Shuman S. (2007) Vaccinia topoisomerase mutants illuminate roles for Phe59, Gly73, Gln69 and Phe215. Virology. 359: 466-76
Tian L, Claeboe CD, Hecht SM, et al. (2005) Mechanistic plasticity of DNA topoisomerase IB: phosphate electrostatics dictate the need for a catalytic arginine. Structure (London, England : 1993). 13: 513-20
Tian L, Sayer JM, Jerina DM, et al. (2004) Individual nucleotide bases, not base pairs, are critical for triggering site-specific DNA cleavage by vaccinia topoisomerase. The Journal of Biological Chemistry. 279: 39718-26
Tian L, Claeboe CD, Hecht SM, et al. (2004) Remote phosphate contacts trigger assembly of the active site of DNA topoisomerase IB. Structure (London, England : 1993). 12: 31-40
Yakovleva L, Tian L, Sayer JM, et al. (2003) Site-specific DNA transesterification by vaccinia topoisomerase: effects of benzo[alpha]pyrene-dA, 8-oxoguanine, 8-oxoadenine and 2-aminopurine modifications. The Journal of Biological Chemistry. 278: 42170-7
Tian L, Claeboe CD, Hecht SM, et al. (2003) Guarding the genome: electrostatic repulsion of water by DNA suppresses a potent nuclease activity of topoisomerase IB. Molecular Cell. 12: 199-208
Tian L, Sayer JM, Kroth H, et al. (2003) Benzo[a]pyrene-dG adduct interference illuminates the interface of vaccinia topoisomerase with the DNA minor groove. The Journal of Biological Chemistry. 278: 9905-11
Pei Y, Lehman K, Tian L, et al. (2000) Characterization of Candida albicans RNA triphosphatase and mutational analysis of its active site. Nucleic Acids Research. 28: 1885-92
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