Shinu John, Ph.D.

Affiliations: 
2007 Biochemistry State University of New York, Buffalo, Buffalo, NY, United States 
Area:
Biochemistry, Immunology
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Parents

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Lee A. Garrett-Sinha grad student 2007 SUNY Buffalo
 (Increased plasma cell differentiation, hyper-responsiveness to TLR9, and loss of peripheral B cell tolerance in mice lacking the transcription factor Ets -1.)
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Publications

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Russell L, John S, Cullen J, et al. (2015) Requirement for Transcription Factor Ets1 in B Cell Tolerance to Self-Antigens. Journal of Immunology (Baltimore, Md. : 1950). 195: 3574-83
Mayeux J, Skaug B, Luo W, et al. (2015) Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels. Journal of Immunology (Baltimore, Md. : 1950)
John S, Russell L, Chin SS, et al. (2014) Transcription factor Ets1, but not the closely related factor Ets2, inhibits antibody-secreting cell differentiation. Molecular and Cellular Biology. 34: 522-32
John SA, Garrett-Sinha LA. (2009) Blimp1: a conserved transcriptional repressor critical for differentiation of many tissues. Experimental Cell Research. 315: 1077-84
Garrett-Sinha LA, John S, Gaffen SL. (2008) IL-17 and the Th17 lineage in systemic lupus erythematosus. Current Opinion in Rheumatology. 20: 519-25
John SA, Clements JL, Russell LM, et al. (2008) Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1. The Journal of Biological Chemistry. 283: 951-62
Clements JL, John SA, Garrett-Sinha LA. (2006) Impaired generation of CD8+ thymocytes in Ets-1-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 177: 905-12
Wang D, John SA, Clements JL, et al. (2005) Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease. International Immunology. 17: 1179-91
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