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Pranav Patel, Ph.D.

Affiliations: 
2008 Florida Institute of Technology, Melbourne, FL, United States 
Area:
Organic Chemistry, Pharmaceutical Chemistry
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Joshua Rokach grad student 2008 Florida Institute of Technology
 (Design and synthesis of affinity chromatography ligands for the isolation of 5-HEDH enzyme: Synthesis of prostanoids and their identification in human urine.)

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Nagendra Reddy C, Ye Q, Patel P, et al. (2017) Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase. Bioorganic & Medicinal Chemistry. 25: 116-125
Patel P, Reddy CN, Gore V, et al. (2014) Two Potent OXE-R Antagonists: Assignment of Stereochemistry. Acs Medicinal Chemistry Letters. 5: 815-9
Gore V, Chourey S, Ye Q, et al. (2014) Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 24: 3385-8
Gore V, Gravel S, Cossette C, et al. (2014) Inhibition of 5-oxo-6,8,11,14-eicosatetraenoic acid-induced activation of neutrophils and eosinophils by novel indole OXE receptor antagonists. Journal of Medicinal Chemistry. 57: 364-77
Gore V, Patel P, Chang CT, et al. (2013) 5-Oxo-ETE receptor antagonists. Journal of Medicinal Chemistry. 56: 3725-32
Grant GE, Rubino S, Gravel S, et al. (2011) Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid. Carcinogenesis. 32: 822-8
Patel P, Gore V, Powell WS, et al. (2011) C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative. Bioorganic & Medicinal Chemistry Letters. 21: 1987-90
Grant GE, Gravel S, Guay J, et al. (2011) 5-oxo-ETE is a major oxidative stress-induced arachidonate metabolite in B lymphocytes. Free Radical Biology & Medicine. 50: 1297-304
Patel P, Anumolu JR, Powell WS, et al. (2011) 5-oxo-15-HETE: total synthesis and bioactivity. Bioorganic & Medicinal Chemistry Letters. 21: 1857-60
Chang CT, Patel P, Gore V, et al. (2009) A new approach to the synthesis of polyunsaturated deuterated isoprostanes: total synthesis of d4-5-epi-8,12-iso-iPF3alpha-VI and d4-8,12-iso-iPF3alpha-VI. Bioorganic & Medicinal Chemistry Letters. 19: 6755-8
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