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Wang-Yong Yang, Ph.D.

Affiliations: 
2011 Florida State University, Tallahassee, FL, United States 
Area:
Organic Chemistry, Biochemistry
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Parents

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Igor V. Alabugin grad student 2011 Florida State
 (Design of pH-controlled light-activated reagents for efficient cleavage of double-stranded DNA and cancer phototherapy.)

Children

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Jennifer C. Stern grad student Florida State

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Publications

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Breiner B, Kaya K, Roy S, et al. (2012) Hybrids of amino acids and acetylenic DNA-photocleavers: optimising efficiency and selectivity for cancer phototherapy. Organic & Biomolecular Chemistry. 10: 3974-87
Yang WY, Roy S, Phrathep B, et al. (2011) Engineering pH-gated transitions for selective and efficient double-strand DNA photocleavage in hypoxic tumors. Journal of Medicinal Chemistry. 54: 8501-16
Yang WY, Marrone SA, Minors N, et al. (2011) Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates. Beilstein Journal of Organic Chemistry. 7: 813-23
Yang W. (2010) Topoisomerases and site-specific recombinases: Similarities in structure and mechanism Critical Reviews in Biochemistry and Molecular Biology. 45: 520-534
Yang WY, Cao Q, Callahan C, et al. (2010) Intracellular DNA damage by lysine-acetylene conjugates. Journal of Nucleic Acids. 2010
Yang WY, Breiner B, Kovalenko SV, et al. (2009) C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy Journal of the American Chemical Society. 131: 11458-11470
Yang W. (2008) Structure and mechanism for DNA lesion recognition Cell Research. 18: 184-197
Yang W. (2007) Human MutLα: The jack of all trades in MMR is also an endonuclease Dna Repair. 6: 135-139
Yang W. (2003) Pruning DNA: Structure-specific endonucleases (XPF/Rad1/Mus81) Structure. 11: 365-366
Yang W. (2003) Damage repair DNA polymerases Y Current Opinion in Structural Biology. 13: 23-30
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