Jason S. Chapman, Ph.D.
Affiliations: | 2004 | University of Wisconsin, Madison, Madison, WI |
Area:
Biochemistry, OncologyGoogle:
"Jason Chapman"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Margaret Clagett-Dame | grad student | 2004 | UW Madison | |
| (Molecular mechanism of action of the synthetic retinoid N-(4-hydroxyphenyl)retinamide.) | ||||
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Publications
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| Anding AL, Chapman JS, Barnett DW, et al. (2007) The unhydrolyzable fenretinide analogue 4-hydroxybenzylretinone induces the proapoptotic genes GADD153 (CHOP) and Bcl-2-binding component 3 (PUMA) and apoptosis that is caspase- dependent and independent of the retinoic acid receptor. Cancer Research. 67: 6270-7 |
| Mershon SM, Anding AL, Chapman JS, et al. (2007) Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogs. Bioorganic & Medicinal Chemistry Letters. 17: 836-40 |
| Chapman JS, Weiss KL, Curley RW, et al. (2003) Hydrolysis of 4-HPR to atRA occurs in vivo but is not required for retinamide-induced apoptosis. Archives of Biochemistry and Biophysics. 419: 234-43 |
| Abou-Issa H, Curley RW, Alshafie GA, et al. (2001) Chemotherapeutic evaluation of 4-hydroxybenzylretinone (4-HBR), a nonhydrolyzable C-linked analog of N-(4-hydroxyphenyl) retinamide (4-HPR) against mammary carcinogenesis. Anticancer Research. 21: 3839-44 |
| Weiss KL, Alshafie G, Chapman JS, et al. (2001) An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide. synthesis and preliminary biological studies. Bioorganic & Medicinal Chemistry Letters. 11: 1583-6 |