Ryan P. Bender, Ph.D.
Affiliations: | 2007 | Vanderbilt University, Nashville, TN |
Area:
Biochemistry, ToxicologyGoogle:
"Ryan Bender"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Neil Osheroff | grad student | 2007 | Vanderbilt | |
| (Quinone metabolites of environmental toxins poison topoisomerase IIalpha.) | ||||
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Publications
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| Bender RP, Jablonksy MJ, Shadid M, et al. (2008) Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity. Biochemistry. 47: 4501-9 |
| Wilstermann AM, Bender RP, Godfrey M, et al. (2007) Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. Biochemistry. 46: 8217-25 |
| Bender RP, Osheroff N. (2007) Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chemical Research in Toxicology. 20: 975-81 |
| Bender RP, Ham AJ, Osheroff N. (2007) Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. Biochemistry. 46: 2856-64 |
| Bender RP, Lehmler HJ, Robertson LW, et al. (2006) Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Biochemistry. 45: 10140-52 |
| Lindsey RH, Bender RP, Osheroff N. (2005) Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites. Chemico-Biological Interactions. 153: 197-205 |
| Lindsey RH, Bender RP, Osheroff N. (2005) Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison. Chemical Research in Toxicology. 18: 761-70 |
| Bender RP, Lindsey RH, Burden DA, et al. (2004) N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison. Biochemistry. 43: 3731-9 |