Sandlin P. Seguin, Ph.D.
Affiliations: | 2011 | University of Pittsburgh, Pittsburgh, PA, United States |
Area:
Virology Biology, Molecular Biology, BiochemistryGoogle:
"Sandlin Seguin"Mean distance: (not calculated yet)
Parents
Sign in to add mentorJeffery L. Brodsky | grad student | 2011 | University of Pittsburgh | |
(Identification of small molecule inhibitors of polyomavirus replication.) |
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Publications
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Ireland AW, Gobillot TA, Gupta T, et al. (2014) Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target. Bioorganic & Medicinal Chemistry. 22: 6490-502 |
Simon N, Bochman ML, Seguin S, et al. (2013) Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase. Bioscience Reports. 33 |
Abisambra J, Jinwal UK, Miyata Y, et al. (2013) Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological Psychiatry. 74: 367-74 |
Miyata Y, Li X, Lee HF, et al. (2013) Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. Acs Chemical Neuroscience. 4: 930-9 |
Seguin SP, Ireland AW, Gupta T, et al. (2012) A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Research. 96: 70-81 |
Seguin SP, Evans CW, Nebane-Akah M, et al. (2012) High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity. Journal of Biomolecular Screening. 17: 194-203 |
Huryn DM, Brodsky JL, Brummond KM, et al. (2011) Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. Proceedings of the National Academy of Sciences of the United States of America. 108: 6757-62 |
Wright CM, Seguin SP, Fewell SW, et al. (2009) Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Research. 141: 71-80 |