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Sandlin P. Seguin, Ph.D.

Affiliations: 
2011 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Virology Biology, Molecular Biology, Biochemistry
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"Sandlin Seguin"
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Jeffery L. Brodsky grad student 2011 University of Pittsburgh
 (Identification of small molecule inhibitors of polyomavirus replication.)
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Publications

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Ireland AW, Gobillot TA, Gupta T, et al. (2014) Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target. Bioorganic & Medicinal Chemistry. 22: 6490-502
Simon N, Bochman ML, Seguin S, et al. (2013) Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase. Bioscience Reports. 33
Abisambra J, Jinwal UK, Miyata Y, et al. (2013) Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological Psychiatry. 74: 367-74
Miyata Y, Li X, Lee HF, et al. (2013) Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. Acs Chemical Neuroscience. 4: 930-9
Seguin SP, Ireland AW, Gupta T, et al. (2012) A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Research. 96: 70-81
Seguin SP, Evans CW, Nebane-Akah M, et al. (2012) High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity. Journal of Biomolecular Screening. 17: 194-203
Huryn DM, Brodsky JL, Brummond KM, et al. (2011) Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. Proceedings of the National Academy of Sciences of the United States of America. 108: 6757-62
Wright CM, Seguin SP, Fewell SW, et al. (2009) Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Research. 141: 71-80
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