Jessica L. Childs-Disney, Ph.D.

2003 University of Rochester, Rochester, NY 
Biochemistry, Physical Chemistry, General Biophysics
"Jessica Childs-Disney"
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Douglas H. Turner grad student 2003 Rochester
 (Oligonucleotide-directed misfolding of RNAs.)
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Liu X, Haniff HS, Childs-Disney JL, et al. (2020) Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands. Journal of the American Chemical Society
Costales MG, Childs-Disney JL, Haniff HS, et al. (2020) How We Think about Targeting RNA with Small Molecules. Journal of Medicinal Chemistry
Disney MD, Suresh BM, Benhamou RI, et al. (2020) Progress toward the development of the small molecule equivalent of small interfering RNA. Current Opinion in Chemical Biology. 56: 63-71
Costales MG, Aikawa H, Li Y, et al. (2020) Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer. Proceedings of the National Academy of Sciences of the United States of America
Zhang P, Park HJ, Zhang J, et al. (2020) Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA. Proceedings of the National Academy of Sciences of the United States of America
Chen JL, Moss WN, Spencer A, et al. (2019) The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology. Plos One. 14: e0219210
Disney MD, Velagapudi SP, Li Y, et al. (2019) Identifying and validating small molecules interacting with RNA (SMIRNAs). Methods in Enzymology. 623: 45-66
O'Leary CA, Andrews RJ, Tompkins VS, et al. (2019) RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression. Plos One. 14: e0213758
Costales MG, Hoch DG, Abegg D, et al. (2019) A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin. Journal of the American Chemical Society
Childs-Disney JL, Tran T, Vummidi BR, et al. (2018) A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence. Chem. 4: 2384-2404
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