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Youhna M. Ayala, Ph.D.

Affiliations: 
2001 Washington University, Saint Louis, St. Louis, MO 
Area:
Biochemistry
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"Youhna Ayala"
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Enrico Di Cera grad student 2001 Washington University
 (Molecular determinants in thrombin -receptor interactions.)

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Publications

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Ayala YM, De Conti L, Avendaño-Vázquez SE, et al. (2011) TDP-43 regulates its mRNA levels through a negative feedback loop. The Embo Journal. 30: 277-88
D'Ambrogio A, Buratti E, Stuani C, et al. (2009) Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo. Nucleic Acids Research. 37: 4116-26
Ayala YM, Zago P, D'Ambrogio A, et al. (2008) Structural determinants of the cellular localization and shuttling of TDP-43. Journal of Cell Science. 121: 3778-85
Ayala YM, Misteli T, Baralle FE. (2008) TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression. Proceedings of the National Academy of Sciences of the United States of America. 105: 3785-9
Ayala YM, Pagani F, Baralle FE. (2006) TDP43 depletion rescues aberrant CFTR exon 9 skipping. Febs Letters. 580: 1339-44
Mercado PA, Ayala YM, Romano M, et al. (2005) Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene. Nucleic Acids Research. 33: 6000-10
Buratti E, Brindisi A, Giombi M, et al. (2005) TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. The Journal of Biological Chemistry. 280: 37572-84
Ayala YM, Pantano S, D'Ambrogio A, et al. (2005) Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function. Journal of Molecular Biology. 348: 575-88
Buratti E, Baralle M, De Conti L, et al. (2004) hnRNP H binding at the 5' splice site correlates with the pathological effect of two intronic mutations in the NF-1 and TSHbeta genes. Nucleic Acids Research. 32: 4224-36
Romano M, Marcucci R, Buratti E, et al. (2002) Regulation of 3' splice site selection in the 844ins68 polymorphism of the cystathionine Beta -synthase gene. The Journal of Biological Chemistry. 277: 43821-9
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