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Ezra R. Lowe, Ph.D.

Affiliations: 
2004 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Pharmacology
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Yoichi Osawa grad student 2004 University of Michigan
 (Metabolism-based inactivation of nitric oxide synthase by constituents of tobacco and related plants.)

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Zhang F, Lowe ER, Rick DL, et al. (2011) In vitro metabolism, glutathione conjugation, and CYP isoform specificity of epoxidation of 4-vinylphenol. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 41: 6-23
Osawa Y, Lau M, Lowe ER. (2007) Plant-Derived Small Molecule Inhibitors of Neuronal NO-Synthase: Potential Effects on Protein Degradation. Plant Signaling & Behavior. 2: 129-30
Lowe ER, Everett AC, Lau M, et al. (2007) Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 14: 344-52
Dunbar AY, Jenkins GJ, Jianmongkol S, et al. (2006) Tetrahydrobiopterin protects against guanabenz-mediated inhibition of neuronal nitric-oxide synthase in vitro and in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1448-56
Kamada Y, Jenkins GJ, Lau M, et al. (2005) Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase. Brain Research. Molecular Brain Research. 142: 19-27
Lowe ER, Everett AC, Lee AJ, et al. (2005) Time-dependent inhibition and tetrahydrobiopterin depletion of endothelial nitric-oxide synthase caused by cigarettes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 131-8
Dunbar AY, Kamada Y, Jenkins GJ, et al. (2004) Ubiquitination and degradation of neuronal nitric-oxide synthase in vitro: dimer stabilization protects the enzyme from proteolysis. Molecular Pharmacology. 66: 964-9
Morishima Y, Kanelakis KC, Murphy PJ, et al. (2003) The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. The Journal of Biological Chemistry. 278: 48754-63
Demady DR, Lowe ER, Everett AC, et al. (2003) Metabolism-based inactivation of neuronal nitric-oxide synthase by components of cigarette and cigarette smoke. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 932-7
Osawa Y, Lowe ER, Everett AC, et al. (2003) Proteolytic degradation of nitric oxide synthase: effect of inhibitors and role of hsp90-based chaperones. The Journal of Pharmacology and Experimental Therapeutics. 304: 493-7
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