Gregory Paul Winter, Ph.D.

Division of Protein and Nucleic Acid Chemistry-Biotechnology MRC Laboratory of Molecular Biology, Cambridge, England, United Kingdom 
therapeutic monoclonal antibodies humanise antibodies, using phage display, antibodies for therapeutic uses
"Gregory Paul Winter"

The Nobel Prize in Chemistry 2018 was divided, one half awarded to Frances H. Arnold "for the directed evolution of enzymes", the other half jointly to George P. Smith and Sir Gregory P. Winter "for the phage display of peptides and antibodies."
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Mean distance: 17.13 (cluster 18)
Cross-listing: Neurotree


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Brian  S. Hartley grad student 1973-1976 MRC-LMB
 (The amino acid sequence of tryptophanyl + RNA synthetase from bacillus stearothermophilus.)
George  G. Brownlee post-doc 1976-1980 MRC-LMB (Neurotree)
 (deduced from


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Stanley Fields grad student 1981 MRC-LMB (Microtree)
Mary Miu Yee WAYE post-doc 1982-1984 MRC-LMB
Dario Neri post-doc 1992-1996 MRC-LMB
Christian Heinis post-doc 2006-2008 MRC-LMB
Hugues Bedouelle research scientist 1984-1986 MRC-LMB
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Heinis C, Winter G. (2015) Encoded libraries of chemically modified peptides. Current Opinion in Chemical Biology. 26: 89-98
Baeriswyl V, Rapley H, Pollaro L, et al. (2012) Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases. Chemmedchem. 7: 1173-6
Angelini A, Cendron L, Chen S, et al. (2012) Bicyclic peptide inhibitor reveals large contact interface with a protease target. Acs Chemical Biology. 7: 817-21
Heinis C, Rutherford T, Freund S, et al. (2009) Phage-encoded combinatorial chemical libraries based on bicyclic peptides. Nature Chemical Biology. 5: 502-7
Brüggemann M, Winter G, Waldmann H, et al. (1989) The immunogenicity of chimeric antibodies. The Journal of Experimental Medicine. 170: 2153-7
Fersht AR, Knill-Jones JW, Bedouelle H, et al. (1988) Reconstruction by site-directed mutagenesis of the transition state for the activation of tyrosine by the tyrosyl-tRNA synthetase: A mobile loop envelopes the transition state in an induced-fit mechanism Biochemistry. 27: 1581-1587
Bedouelle H, Winter G. (1986) A model of synthetase/transfer RNA interaction as deduced by protein engineering Nature. 320: 371-373
Jones PT, Dear PH, Foote J, et al. (1986) Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature. 321: 522-5
Waye MM, Winter G. (1986) A transcription terminator in the 5' non-coding region of the tyrosyl tRNA synthetase gene from Bacillus stearothermophilus. European Journal of Biochemistry. 158: 505-10
Carter P, Bedouelle H, Winter G. (1986) Construction of heterodimer tyrosyl-tRNA synthetase shows tRNA(Tyr) interacts with both subunits Proceedings of the National Academy of Sciences of the United States of America. 83: 1189-1192
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