Aleem Gangjee
Affiliations: | Medicinal Chemistry | Duquesne University, Pittsburgh, PA, United States |
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Children
Sign in to add trainee| Xin Lin | grad student | 1997-2005 | Duquesne University (Neurotree) |
| Udaya K. Kotreka | grad student | 2011 | Duquesne University |
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| Katinas JM, Nayeen MJ, Schneider M, et al. (2024) Structural Characterization of 5-Substituted Pyrrolo[3,2-]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry |
| Kaku K, Ravindra MP, Tong N, et al. (2023) Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport. Acs Medicinal Chemistry Letters. 14: 1682-1691 |
| Nayeen MJ, Katinas JM, Magdum T, et al. (2023) Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria. Journal of Medicinal Chemistry. 66: 11294-11323 |
| Tong N, Wong-Roushar J, Wallace-Povirk A, et al. (2023) Multitargeted 6-Substituted Thieno[2,3-]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism. Acs Pharmacology & Translational Science. 6: 748-770 |
| Choudhary S, Kaku K, Robles AJ, et al. (2023) Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site. Bioorganic & Medicinal Chemistry. 82: 117217 |
| Wallace-Povirk A, Rubinsak L, Malysa A, et al. (2022) Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment. Scientific Reports. 12: 11346 |
| Islam F, Doshi A, Robles AJ, et al. (2022) Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-]pyrimidines as Microtubule Targeting Agents. Molecules (Basel, Switzerland). 27 |
| Wallace-Povirk A, Tong N, Wong-Roushar J, et al. (2021) Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors. Bioorganic & Medicinal Chemistry. 37: 116093 |
| Islam F, Quadery TM, Bai R, et al. (2021) Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in Vitro and in Vivo evaluation as antitumor agents. Bioorganic & Medicinal Chemistry Letters. 127923 |
| Choudhary S, Doshi A, Luckett-Chastain L, et al. (2021) Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer. Bioorganic & Medicinal Chemistry. 35: 116061 |