Anthony Schwacha

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Molecular Biology, Genetics, Biochemistry
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"Anthony Schwacha"
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Vijayraghavan S, Tsai FL, Schwacha A. (2016) A Checkpoint-Related Function of the MCM Replicative Helicase Is Required to Avert Accumulation of RNA:DNA Hybrids during S-phase and Ensuing DSBs during G2/M. Plos Genetics. 12: e1006277
Bochman ML, Schwacha A. (2015) DNA replication: Strand separation unravelled. Nature. 524: 166-7
Tsai FL, Vijayraghavan S, Prinz J, et al. (2015) Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate. Molecular and Cellular Biology. 35: 2131-43
Simon NE, Schwacha A. (2014) The Mcm2-7 replicative helicase: a promising chemotherapeutic target. Biomed Research International. 2014: 549719
Simon N, Bochman ML, Seguin S, et al. (2013) Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase. Bioscience Reports. 33
Vijayraghavan S, Schwacha A. (2012) The eukaryotic Mcm2-7 replicative helicase. Sub-Cellular Biochemistry. 62: 113-34
Bochman ML, Schwacha A. (2010) The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'. Nucleic Acids Research. 38: 6078-88
Bochman ML, Schwacha A. (2009) The Mcm complex: unwinding the mechanism of a replicative helicase. Microbiology and Molecular Biology Reviews : Mmbr. 73: 652-83
Bochman ML, Bell SP, Schwacha A. (2008) Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability Molecular and Cellular Biology. 28: 5865-5873
Bochman ML, Schwacha A. (2008) The Mcm2-7 complex has in vitro helicase activity. Molecular Cell. 31: 287-93
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