Loren D. Walensky

Affiliations: 
Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
Area:
General Chemistry, Molecular Biology
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"Loren Walensky"
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Publications

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Howard TP, Arnoff TE, Song MR, et al. (2019) MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. Cancer Research
Guerra RM, Bird GH, Harvey EP, et al. (2018) Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer. Cell Reports. 24: 3393-3403.e5
Stolte B, Iniguez AB, Dharia NV, et al. (2018) Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in wild-type Ewing sarcoma. The Journal of Experimental Medicine
Escudero S, Zaganjor E, Lee S, et al. (2018) Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. Molecular Cell. 69: 729-743.e7
Rezaei Araghi R, Bird GH, Ryan JA, et al. (2018) Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. Proceedings of the National Academy of Sciences of the United States of America
Harvey EP, Seo HS, Guerra RM, et al. (2018) Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor. Structure (London, England : 1993). 26: 153-160.e4
Pease-Raissi SE, Pazyra-Murphy MF, Li Y, et al. (2017) Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration. Neuron. 96: 373-386.e6
Reyna DE, Garner TP, Lopez A, et al. (2017) Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 32: 490-505.e10
Pritz JR, Wachter F, Lee S, et al. (2017) Allosteric sensitization of proapoptotic BAX. Nature Chemical Biology
Edwards AL, Meijer DH, Guerra RM, et al. (2016) Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides. Acs Chemical Biology
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