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Thomas Armand Wilson

Clinical Lab and Nutritional Siences University of Massachusetts Lowell, MA 01854 USA 
Nutrition, Biochemistry
"Thomas Armand Wilson"
The influence of body composition, gonadal steroid status and gender on serum carotenoids and retinol. Wilson, Thomas Armand, Ph.D. University of Rhode Inland, 1992. 180pp.
Order Number DA92S9600
The relationships of serum beta-carotene, lutein, zeaxanthin and retinol concentrations with body composition, serum estradiol concentrations, phase of menstrual cycle, use of oral contraceptive agents (OCA's) and gender were examined in 55 subjects taking SO mg supplements of beta-carotene daily for 28 days. Serum samples were collected from all subjects prior to supplementation, 8 hours following a single dose and on day 28 of supplementation. Serum carotenoids and retinol were measured by HPLC and serum estradiol and progesterone were measured by RIA. Baseline serum retinol concentrations were significantly higher (p < .01) in females using OCA's than in females not using OCA's. Baseline serum retinol concentrations were also significantly higher (p < .005) in males than in females not using OCA's, with the same body composition. Baseline serum beta-carotene concentrations were negatively correlated to percent body fat (r = —.5471; p < .01) and total body fat (r = - .5477; p < .01) in females. All groups had significantly higher (p < .05) serum beta-carotene concentrations at day-28 compared to initial concentrations. Also, all groups, except the low-body-fat groups, had significantly higher (p < .05) serum beta- carotene concentrations at 8-hours following a single dose compared to initial concentrations. These findings identify that the impact of personal characteristics on serum carotenoid and retinol concentrations is minimized when the individual is challenged with high doses of beta- carotene either acutely or chronically.
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Bagul M, Kakumanu S, Wilson TA. (2015) Crude Garlic Extract Inhibits Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis of Cancer Cells In Vitro. Journal of Medicinal Food. 18: 731-7
Rozati M, Barnett J, Wu D, et al. (2015) Cardio-metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial Nutrition and Metabolism. 12
Kakumanu S, Tagne JB, Wilson TA, et al. (2011) A nanoemulsion formulation of dacarbazine reduces tumor size in a xenograft mouse epidermoid carcinoma model compared to dacarbazine suspension. Nanomedicine : Nanotechnology, Biology, and Medicine. 7: 277-83
Edmund AR, Kambalapally S, Wilson TA, et al. (2011) Encapsulation of cadmium selenide quantum dots using a self-assembling nanoemulsion (SANE) reduces their in vitro toxicity. Toxicology in Vitro : An International Journal Published in Association With Bibra. 25: 185-90
Vishwanathan R, Gendron CM, Goodrow-Kotyla EF, et al. (2010) Increased consumption of dietary cholesterol, lutein, and zeaxanthin as egg yolks does not decrease serum concentrations and lipoprotein distribution of other carotenoids, retinol, and tocopherols. Nutrition Research (New York, N.Y.). 30: 747-55
Vishwanathan R, Goodrow-Kotyla EF, Wooten BR, et al. (2009) Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in older adults with low macular pigment taking cholesterol-lowering statins. The American Journal of Clinical Nutrition. 90: 1272-9
Kuo F, Subramanian B, Kotyla T, et al. (2008) Nanoemulsions of an anti-oxidant synergy formulation containing gamma tocopherol have enhanced bioavailability and anti-inflammatory properties. International Journal of Pharmaceutics. 363: 206-13
Wilson TA, Nicolosi RJ, Woolfrey B, et al. (2007) Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters. The Journal of Nutritional Biochemistry. 18: 105-12
Wilson TA, Nicolosi RJ, Kotyla T, et al. (2007) Soy protein without isoflavones reduces aortic total and cholesterol ester concentrations greater than soy protein with isoflavones compared with casein in hypercholesterolemic hamsters Nutrition Research. 27: 498-504
Wilson TA, Orthoefer F, Nicolosi RJ. (2007) Soy protein concentrate lowers serum high-density lipoprotein cholesterol concentrations compared with casein in ovariectomized rats fed a low-fat, cholesterol-free diet Nutrition Research. 27: 417-422
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