Nancy C. Horton
Affiliations: | Biochemistry | University of Arizona, Tucson, AZ |
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Publications
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| Ghadirian N, Morgan RD, Horton NC. (2024) DNA Sequence Control of Enzyme Filamentation and Activation of the SgrAI Endonuclease. Biochemistry |
| Lyumkis D, Horton NC. (2022) The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI. Biochemical Society Transactions. 50: 1703-1714 |
| Sanchez JL, Ghadirian N, Horton NC. (2022) High-Resolution Structure of the Nuclease Domain of the Human Parvovirus B19 Main Replication Protein NS1. Journal of Virology. e0216421 |
| Shan Z, Ghadirian N, Lyumkis D, et al. (2022) Pretransition state and apo structures of the filament-forming enzyme SgrAI elucidate mechanisms of activation and substrate specificity. The Journal of Biological Chemistry. 298: 101760 |
| Park CK, Horton NC. (2019) Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation. Biophysical Reviews |
| Polley S, Lyumkis D, Horton NC. (2019) Mechanism of Filamentation-Induced Allosteric Activation of the SgrAI Endonuclease. Structure (London, England : 1993) |
| Xu P, Ganaie SS, Wang X, et al. (2018) Endonuclease Activity Inhibition of the NS1 Protein of Parvovirus B19 as a Novel Target for Antiviral Drug Development. Antimicrobial Agents and Chemotherapy |
| Barahona C, Basantes LE, Tompkins KJ, et al. (2018) The Need for Speed: Run-On Oligomer Filament Formation Provides Maximum Speed with Maximum Sequestration of Activity. Journal of Virology |
| Park CK, Sanchez JL, Barahona C, et al. (2018) The run-on oligomer filament enzyme mechanism of SgrAI. Part 1: Assembly kinetics of the run-on oligomer filament. The Journal of Biological Chemistry |
| Park CK, Sanchez JL, Barahona C, et al. (2018) The run-on oligomer filament enzyme mechanism of SgrAI. Part 2: Kinetic modeling of the full DNA cleavage pathway. The Journal of Biological Chemistry |