Percy Tumbale, Ph.D.

Affiliations: 
2009 Florida Atlantic University, Boca Raton, FL, United States 
Area:
Biochemistry, Biomedical Engineering, Molecular Biology
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"Percy Tumbale"
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Keith Brew grad student 2009 Florida Atlantic University
 (Structure-function relationships in eukaryotic and prokaryotic family 6 glycosyltransferases.)
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Publications

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Schellenberg MJ, Tumbale PP, Williams RS. (2015) Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease. Progress in Biophysics and Molecular Biology. 117: 157-65
Andres SN, Schellenberg MJ, Wallace BD, et al. (2015) Recognition and repair of chemically heterogeneous structures at DNA ends. Environmental and Molecular Mutagenesis. 56: 1-21
Tumbale P, Williams JS, Schellenberg MJ, et al. (2014) Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Nature. 506: 111-5
Thiyagarajan N, Pham TT, Stinson B, et al. (2012) Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen. Scientific Reports. 2: 940
Tumbale P, Appel CD, Kraehenbuehl R, et al. (2011) Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease. Nature Structural & Molecular Biology. 18: 1189-95
Brew K, Tumbale P, Acharya KR. (2010) Family 6 glycosyltransferases in vertebrates and bacteria: inactivation and horizontal gene transfer may enhance mutualism between vertebrates and bacteria. The Journal of Biological Chemistry. 285: 37121-7
Tumbale P, Brew K. (2009) Characterization of a metal-independent CAZy family 6 glycosyltransferase from Bacteroides ovatus. The Journal of Biological Chemistry. 284: 25126-34
Jamaluddin H, Tumbale P, Ferns TA, et al. (2009) Crystal structure of alpha-1,3-galactosyltransferase (alpha3GT) in a complex with p-nitrophenyl-beta-galactoside (pNPbetaGal). Biochemical and Biophysical Research Communications. 385: 601-4
Tumbale P, Jamaluddin H, Thiyagarajan N, et al. (2008) Screening a limited structure-based library identifies UDP-GalNAc-specific mutants of alpha-1,3-galactosyltransferase. Glycobiology. 18: 1036-43
Tumbale P, Jamaluddin H, Thiyagarajan N, et al. (2008) Structural basis of UDP-galactose binding by alpha-1,3-galactosyltransferase (alpha3GT): role of negative charge on aspartic acid 316 in structure and activity. Biochemistry. 47: 8711-8
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